Most significant move: It was already known that All-Pro inside linebacker NaVorro Bowman would miss half of the season after his gruesome left knee injury in the NFC title game last January, but it was made official with Bowman being placed on the reserve/physically unable to perform list on Monday. As such, he has to sit out at least the first six weeks of the season. At the end of that sixth week, Bowman then has three weeks to begin practicing and once he does get on the practice field, he has three weeks to join the active 53-man roster. In short, Bowman could be in a game as soon as Week 7 at the Denver Broncos and as late as Week 15, at the Seattle Seahawks, to be eligible to play in the postseason.

Wild card: Marcus Lattimore entered training camp fully expecting to be practicing after missing all of last season recovering from the injury to his right knee suffered in 2012. Alas, he never made it. Now, being placed on the reserve/non-football injury list, Lattimore must sit out at least the first six weeks of the season. Still, coach Jim Harbaugh insisted earlier this summer that Lattimore would be a part of this team this season. And with Jewel Hampton waived, you wonder if the 49ers are holding an active spot for him down the road.

49ers’ cuts: QB McLeod Bethel-Thompson, S D.J. Campbell, TE Kevin Greene, RB Jewel Hampton, P Colton Schmidt, LB Kion Wilson, WR Devon Wylie all waived while WR David Reed was released. RB Marcus Lattimore, FB Trey Millard, CB Keith Reaser and G Brandon Thomas placed on reserve/non-football injury list and LB NaVorro Bowman, TE Garrett Celek and DT Kaleb Ramsey were put on the reserve/physically unable to perform list. Also, LB Blake Costanzo was released from injured reserve.