In Week 5, Arizona Cardinals wide receiver Rondale Moore caught 7 of 8 targets in the passing game while being utilized as a motion/movement player in coach Kliff Klingsbury's offense. He's got a positive Week 6 matchup against the Seattle Seahawks' defense this Sunday and, perhaps more importantly, is still available in over 80% of ESPN fantasy leagues.
Along with Moore, I've identified the players -- all rostered in less than 50% of ESPN leagues -- who can be picked up for this week's slate of NFL games. I've targeted multiple quarterbacks this week, a tight end who can run after the catch, and a rookie running back with receiving traits. While you might notice some overlap with Eric Moody's pickup column that publishes on Mondays, an important distinction is that the options mentioned in this column are focused solely on this week's matchup and not the players' values for the remainder of the season.
With all of that in mind, let's get into it for Week 6's streaming pickup options.
Quarterbacks
Jimmy Garoppolo, San Francisco 49ers (15.2% rostered; at Falcons): Garoppolo posted multiple TD passes for the first time this year in Week 5, finishing with a season-best 18.02 fantasy points in the win over the Panthers. With Atlanta up next, Garoppolo fits here as a streaming option due to the answers on offense I expect from Kyle Shanahan. Look for the ball to be out quick when Garoppolo reads pressure -- slants, unders, the WR screens to Deebo Samuel. Plus, given the amount of 2-3 deep zone we see from the Falcons' defense, Shanahan can scheme open voids at the second level. Those are timing and anticipatory throws from Jimmy G -- clear-and-replace concepts that create the catch-and-run opportunities in the 49ers' system.
Geno Smith, Seattle Seahawks (70.6% rostered; vs. Cardinals): We wrote about Smith here last week, and we will continue to hit on the Seahawks quarterback as a matchup-based QB1. Smith, who has now thrown for seven touchdowns over his past three games (with at least 18 fantasy points per game), gets the Cardinals' defense in Week 6. It's another positive matchup for Smith, who is playing with confidence in the pocket, finding his second- and third-level reads, and delivering the ball in rhythm. He's rolling, with DK Metcalf and Tyler Lockett creating separation in the route tree. He's the most-added player of the week, so he may not be available in your league anymore.
Other potential options: Zach Wilson, New York Jets (17.3% rostered; at Packers)
Running backs
Mike Boone, Denver Broncos (32.5% rostered; at Chargers): Playing as the No. 2 back behind Melvin Gordon III in Week 5, Boone logged 85 total yards (on 10 touches) and finished with 11.5 PPR points. Now, let's flip that usage to the Week 6 matchup against a Chargers defense that has been gutted in the run game. Through five weeks, Los Angeles is giving up a league-worst 5.32 yards per carry. That's bad football. Yes, the Broncos just added veteran running back Latavius Murray to the mix, too. Still, I'll take a chance on Boone getting 10 to 12 touches this Sunday as a possible flex in deeper leagues.
Rachaad White, Tampa Bay Buccaneers (25.0% rostered; at Steelers): Against a Pittsburgh defense that is reeling right now, let's go with White as a PPR option in deeper leagues. The rookie has now caught all eight of his targets over his past two games, and QB Tom Brady will see Cover 2 from the Steelers' defense on Sunday. That means more underneath flat and check-down options for White, who should get some work in the run game, too.
Other potential options: Eno Benjamin, Arizona Cardinals (33.4% rostered; at Seahawks); Joshua Kelley, Los Angeles Chargers (4.1% rostered; vs. Broncos)
Wide receivers
Rondale Moore, Arizona Cardinals (37.9% rostered; vs. Seahawks): Moore posted 13.1 PPR points (on nine touches) in the Week 5 loss to the Eagles. This is exactly the type of deployment we expected of Moore in Kliff Kingsbury's offense -- slot targets, screens, run-game touches, versatility in the scheme, lots of unders and quicks to get him in a position to create in space. He's dynamic with the ball in his hands. With a matchup versus the Seahawks on Sunday, you can play Moore as a WR3 with PPR upside.
Alec Pierce, Indianapolis Colts (21.4% rostered; vs. Jaguars): In Weeks 3 and 4, we saw the explosive play ability of Pierce as a boundary/vertical target for QB Matt Ryan. In Week 5, the rookie wide receiver caught a team-high 8 of 9 targets for 81 yards in the win over the Broncos. Pierce has now logged 20 targets over his past three games with 15 receptions. He's working to all three levels of the field in the Colts' route tree. I still see more value here for Pierce in non-PPR formats as a deeper-league WR3 for the Week 6 game versus the Jaguars.
Other potential options: Marvin Jones Jr., Jacksonville Jaguars (30.1% rostered; at Colts); Khalil Shakir, Buffalo Bills (1.3% rostered; at Chiefs); Ben Skowronek, Los Angeles Rams (1.0% rostered; vs. Panthers)
Tight ends
Taysom Hill, New Orleans Saints (50.3% rostered; vs. Bengals): Hill's 34.09 PPR points in Week 5 -- and his offensive deployment in the game plan -- should pique your interest. Hill logged 121 yards rushing out of Wildcat sets on Sunday with four total touchdowns (three rushing, one passing). Now, the call sheet could shift if QB Jameis Winston and WR Michael Thomas return for Week 6, which might limit Hill's overall usage. However, if you play in a deeper 12-to-14-team league, I would still take a shot on Hill versus the Bengals this Sunday. He's now seen 14 carries over his past two games (with four total rushing scores), and the Wildcat schemes are a critical piece to what the Saints do in the low red zone. Only Geno Smith has been added in a higher percentage of leagues this week, but Hill is still out there in about half of ESPN leagues heading into the weekend.
Evan Engram, Jacksonville Jaguars (24.1% rostered; at Colts): I streamed Engram in my home league this past week (for an injured Kyle Pitts), and I'll keep him in my lineup if the Falcons tight end is still down with a hamstring for Week 6. Engram caught 6 of 10 targets Sunday versus the Texans, logging 69 yards receiving and a season-high 12.9 PPR points. He's a prime target for QB Trevor Lawrence on unders and crossers, which create room to roll after the catch. Engram, who gets the Colts' defense Sunday, posted 11.6 PPR points (on seven receptions) against Indianapolis in Week 2.
Other potential options: Hayden Hurst, Cincinnati Bengals (45.2% rostered; at Saints); Robert Tonyan, Green Bay Packers (26.6% rostered; vs. Jets)
Defense/special teams
Los Angeles Rams (76.0% rostered; vs. Panthers): Carolina quarterback Baker Mayfield is banged up (foot). If he can't go, it will most likely be a matchup of PJ Walker versus the Rams' defense on Sunday. The Carolina passing game has lacked efficiency and explosive-play juice through the first five weeks of the season, and I would have concerns on the pass protection against the Rams' defensive front. Defensive coordinator Raheem Morris will have opportunities to scheme five-man pressures, plus one-on-ones for Aaron Donald. Scoop up this Rams unit if you need a defense for Week 6, if they are somehow still available after waivers ran earlier this week. They are the most-added D/ST of the week.
Other potential options: New England Patriots (20.1% rostered; at Browns)