Predicting NFL Week 6 upset picks, fantasy football sleepers and flops, plus buzz and notes around the league

We're heading into Week 6 of the 2021 NFL season, and it has been a busy week around the league. We asked ESPN insiders Dan Graziano and Jeremy Fowler for some insight on the biggest news and for their picks on games and players to watch.

How could the Las Vegas Raiders replace Jon Gruden in 2022? Can the Seattle Seahawks still be playoff contenders after losing Russell Wilson for at least a month? Are the Jacksonville Jaguars going to stick with Urban Meyer through the season?

Graziano and Fowler also share their upset picks for Week 6, including a matchup between the Cleveland Browns and Arizona Cardinals. And for fantasy managers looking to make all the right moves, they name must-start sleepers and point out potential fantasy flops of the week (This section might include Tom Brady). They get into all of it, emptying their notebooks with everything they've heard this week, including an update on Baker Mayfield's contract talks, when to expect Baltimore Ravens rookie Rashod Bateman back and what Saquon Barkley's injury means for the New York Giants' future.

Let's get started with the upset picks of the week, but you can also jump to other big questions for Week 6.

Jump to:
Upsets | Seahawks' outlook
Gruden's replacement | Meyer's future
Fantasy flops | Underrated gems
Notebook: Everything we're hearing

Jon Gruden is out as Raiders coach. Who should be on Las Vegas' list of potential replacements?