Week 6 of the NFL season gets underway with a matchup of NFC East rivals when the Philadelphia Eagles visit the New York Giants on "Thursday Night Football."
The Eagles are coming off their first loss of the season, 21-17 to the Denver Broncos, in which they were outscored 18-0 in fourth quarter.
The Giants, meanwhile, dropped to 1-4, losing to a previously winless New Orleans Saints team.
Philadelphia, the odds-on favorite in the NFC East (-225), won both matchups with the Giants last season and is a 7.5-point favorite in Thursday's matchup. Saquon Barkley has the best odds to score a touchdown at -155.
Here are the odds and trends, plus picks, props and analysis from our experts to help you bet the game.
Note: Odds at time of publication. For the latest updates, visit ESPN BET. 
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Game picks | Prop bets | Betting trends
Game bets
Maldonado: This number is pricing in a version of the Eagles that hasn't really shown up this season. Yes, they're the better team, but not by this margin, not with a new OC trying to find his groove. Philly's offense has been clunky and inconsistent, ranking near the bottom of the league in yards per play and struggling to generate big gains. The Giants, meanwhile, run more plays per game and can drag this into the kind of slow, ugly matchup where every possession matters. Add in the fact that Philadelphia's turnover luck is unlikely to stay this clean all season, and the gap starts to shrink even more. If this game turns into a grind -- let's say field goals instead of touchdowns, long drives instead of explosive plays -- then +7.5 suddenly feels like too much. This is about the number being too high for how these teams are actually playing right now.
Notable player props, bets
Jalen Hurts to go UNDER 197.5 passing yards (-115)
Moody: Hurts has gone under this line in three of five games this season. The Eagles enter as favorites and are likely to lean on their offensive line and a running game led by Saquon Barkley, especially against a Giants defensive front that ranks seventh in pass rush win rate. These teams are tied for eighth in rushing attempts per game, which could further limit Hurts' passing volume given the expected lower number of drives. The Giants have allowed 237.2 passing yards per game (24th in the NFL) and 140.0 rushing yards per game (26th), implying the Eagles could find more success on the ground.
Theo Johnson to go OVER 3.5 receptions (-115)
Bowen: Johnson has the alignment versatility to work multiple levels of the field in the pass game, and he can operate as an underneath outlet for quarterback Jaxson Dart versus the Eagles' zone coverages. Johnson caught a season-high six passes against the New Orleans Saints in Week 5, including two touchdowns on red zone throws.
Abdul Carter to go OVER 0.5 sacks (+190)
Walder: Carter is absolutely scorching hot right now, with a 36% pass rush win rate over the past two weeks that ranks third among all players in that span. It's true, playing as a heavy underdog against a team that leans toward the run isn't ideal. But that kind of recent performance can't be ignored. The fact that my model makes this price +148 but doesn't place extra weight on the most recent two games means I love this over.
Betting trends
Courtesy of ESPN Research
The Eagles have won 10 consecutive prime-time meetings against the Giants.
The Giants have lost eight consecutive games against NFC East opponents, the longest active losing streak in division games in the NFL.
The Broncos overcame a 14-point fourth-quarter deficit to stun the Eagles last week. Denver was as long as 25-1 on the live line.
The Eagles have fewer yards than their opponent in all five games this season.