Week 6 gets underway with a matchup of NFC East rivals as the Philadelphia Eagles visit the New York Giants on "Thursday Night Football."
The Eagles won both matchups last season and are early 7.5-point favorites for Thursday's game.
Sunday features an intriguing matchup of 4-1 teams, with the Tampa Bay Buccaneers (-2.5) hosting the San Francisco 49ers, and concludes with the Kansas City Chiefs (-1.5) taking on the Detroit Lions.
The week finishes with a Monday night doubleheader, leading off with the Buffalo Bills (-3.5) facing the Atlanta Falcons and wrapping up with the Chicago Bears visiting the Washington Commanders (-4.5).
It's a bye week for a pair of teams, as the Minnesota Vikings, fresh off two international games, and the Houston Texans are resting.
Here's a look at the odds for every Week 6 game.
Odds as of publication time. For the most current odds, visit ESPN BET.
Jump to:
PHI-NYG | DEN-NYJ | LAC-MIA | ARI-IND
DAL-CAR | NE-NO | LAR-BAL | SEA-JAX
CLE-PIT | TEN-LV | SF-TB | CIN-GB
DET-KC | BUF-ATL | CHI-WSH
Philadelphia Eagles -7.5 vs. New York Giants
Thursday, 8:15 p.m., Prime Video
Money line: Eagles (-400); Giants (+300)
Total: 41.5; Opened: 42.5
FPI favorite: Eagles by 10 with a 74.93% probability to win outright
Denver Broncos -7.5 vs. New York Jets
Sunday, 9:30 a.m. ET, NFL Net, NFL+
Money line: Broncos (-400); Jets (+300)
Total: 43.5; Opened: 43.5
FPI favorite: Broncos by 8.4 with a 71.13% probability to win outright
Los Angeles Chargers -3.5 vs. Miami Dolphins
Sunday, 1 p.m., CBS
Line movement: Opened Chargers -5.5
Money line: Chargers (-210); Dolphins (+175)
Total: 45.5; Opened: 45.5
FPI favorite: Chargers by 4 with a 60.53% probability to win outright
Arizona Cardinals vs. Indianapolis Colts -6.5
Sunday, 1 p.m., Fox
Money line: Cardinals (+225); Colts (-275)
Total: 46.5; Opened: 46.5
FPI favorite: Colts by 6 with a 65.2% probability to win outright
Dallas Cowboys -3.5 vs. Carolina Panthers
Sunday, 1 p.m., Fox
Money line: Cowboys (-185); Panthers (+155)
Total: 49.5; Opened: 48.5
FPI favorite: Cowboys by 4.2 with a 60.93% probability to win outright
New England Patriots -3.5 vs. New Orleans Saints
Sunday, 1 p.m., CBS
Money line: Patriots (-200); Saints (+170)
Total: 45.5; Opened: 46.5
FPI favorite: Patriots by 4.2 with a 60.53% probability to win outright
Los Angeles Rams -7.5 vs. Baltimore Ravens
Sunday, 1 p.m., Fox
Money line: Rams (-400); Ravens (+300)
Total: 45.5; Opened: 44.5
FPI favorite: Rams by 3.4 with a 59.75% probability to win outright
Seattle Seahawks -1.5 vs. Jacksonville Jaguars
Sunday, 1 p.m., Fox
Line movement: Opened Jaguars -1.5
Money line: Seahawks (-120); Jaguars (+100)
Total: 44.5; Opened: 44.5
FPI favorite: Seahawks by 0.3 with a 50.48% probability to win outright
Cleveland Browns vs. Pittsburgh Steelers -4.5
Sunday, 1 p.m., CBS
Money line: Browns (+200); Steelers (-240)
Total: 37.5; Opened: 38.5
FPI favorite: Steelers by 5.2 with a 64.33% probability to win outright
Tennessee Titans vs. Las Vegas Raiders -5.5
Sunday, 4:05 p.m., Fox
Money line: Titans (+220); Raiders (-270)
Total: 41.5; Opened: 41.5
FPI favorite: Raiders by 5.8 with a 64.53% probability to win outright
San Francisco 49ers vs. Tampa Bay Buccaneers -2.5
Sunday, 4:25 p.m., CBS
Money line: 49ers (+135); Buccaneers (-155)
Total: 47.5; Opened: 46.5
FPI favorite: Buccaneers by 0.4 with a 51.33% probability to win outright
Cincinnati Bengals vs. Green Bay Packers -14.5
Sunday, 4:25 p.m., CBS
Money line: Bengals (+800); Packers (-1600)
Total: 44.5; Opened: 43.5
FPI favorite: Packers by 13 with an 80.2% probability to win outright
Detroit Lions vs. Kansas City Chiefs -1.5
Sunday, 8:20 p.m., NBC
Money line: Lions (-105); Chiefs (-115)
Total: 49.5; Opened: 48.5
FPI favorite: Chiefs by 1.3 with a 53.56% probability to win outright
Buffalo Bills -3.5 vs. Atlanta Falcons
Monday, 7:15 p.m., ESPN
Money line: Bills (-195); Falcons (+165)
Total: 48.5; Opened: 49.5
FPI favorite: Bills by 4.2 with a 60.87% probability to win outright
Chicago Bears vs. Washington Commanders -4.5
Monday, 8:15 p.m., ABC
Money line: Bears (+175); Commanders (-210)
Total: 50.5; Opened: 49.5
FPI favorite: Commanders by 5.7 with a 64.67% probability to win outright