Week 2 gets started with a matchup between the Washington Commanders and Green Bay Packers, two playoff teams from last season, at Lambeau Field on Thursday night. Both teams won their Week 1 games.
There are several compelling matchups Sunday, including the Chicago Bears visiting the Detroit Lions (-4.5) in early window and the Atlanta Falcons visiting the Minnesota Vikings (-4.5) on "Sunday Night Football," but Week 2's biggest game is a Super Bowl rematch between the Philadelphia Eagles (-1.5)and Kansas City Chiefs at Arrowhead Stadium.
The week wraps up with a "Monday Night Football" doubleheader, with the Houston Texans (-2.5) histing the Tampa Bay Buccaneers (7 p.m. ET on ABC/ESPN) followed by the Los Angeles Chargers (-3.5) visiting the Las Vegas Raiders (10 p.m. ET on ESPN).
Here's a look at the opening odds for every Week 2 game.
For the most current odds, visit ESPN BET.
Jump to:
WAS-GB | JAX-CIN | BUF-NYJ | SEA-PIT
LAR-TEN | SF-NO | CHI-DET | NYG-DAL
NE-MIA | CLE-BAL | CAR-ARI | DEN-IND
PHI-KC | ATL-MIN | TB-HOU | LAC-LV

Thursday
Washington Commanders at Green Bay Packers -3.5 (-110)
8:15 p.m. ET on Prime Video, Lambeau Field, Green Bay, Wis.
Money line: Packers -190, Commanders +160
Total: 47.5 points
FPI favorite: Packers by 2.0, 54.1% to win outright
Sunday
Jacksonville Jaguars at Cincinnati Bengals -3.5 (-115)
1 p.m. ET, Paycor Stadium, Cincinnati
Money line: Bengals -185, Jaguars +155
Total: 50.5 points
FPI favorite: Bengals by 5.5, 63.7% to win outright
Buffalo Bills -7.5 (+105) at New York Jets
1 p.m. ET, MetLife Stadium, East Rutherford, NJ
Money line: Bills -320, Jets +260
Total: 45.5 points
FPI favorite: Bills by 7.2, 66.6% to win outright
Check out the latest odds and lines for every game on ESPN BET.
Seattle Seahawks at Pittsburgh Steelers -2.5 (-115)
1 p.m. ET, Acrisure Stadium, Pittsburgh
Money line: Steelers -145, Seahawks +125
Total: 40.5 points
FPI favorite: Steelers by 3.0, 57.8% to win outright
Los Angeles Rams -5.5 (+100) at Tennessee Titans
1 p.m. ET, Nissan Stadium, Nashville
Money line: Rams -275, Titans +225
Total: 41.5 points
FPI favorite: Rams by 5.1, 63.2% to win outright
San Francisco 49ers -7.5 (+105) at New Orleans Saints
1 p.m. ET, Caesars Superdome, New Orleans
Money line: 49ers -275, Saints +225
Total: 43.5 points
FPI favorite: 49ers by 6.1, 64.1% to win outright
Chicago Bears at Detroit Lions -5.5 (-105)
1 p.m. ET, Ford Field, Detroit
Money line: Lions -225, Bears +190
Total: 47.5 points
FPI favorite: Lions by 5.8, 63.7% to win outright
New York Giants at Dallas Cowboys -3.5 (-120)
1 p.m. ET, AT&T Stadium, Arlington, Texas
Money line: Cowboys -250, Giants +210
Total: 44.5 points
FPI favorite: Cowboys by 4.0, 60.8% to win outright
New England Patriots at Miami Dolphins -1.5 (-110)
1 p.m. ET, Hard Rock Stadium, Miami Gardens, Fla.
Money line: Dolphins -130, Patriots +110
Total: 44.5 points
FPI favorite: Dolphins by 2.5, 55.8% to win outright
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Cleveland Browns at Baltimore Ravens -12.5 (-105)
4:05 p.m. ET, M&T Bank Stadium, Baltimore
Money line: Ravens -900, Browns +550
Total: 44.5 points
FPI favorite: Ravens by 11.6, 76.9% to win outright
Carolina Panthers at Arizona Cardinals -6.5 (-105)
4:05 p.m. ET, State Farm Stadium, Glendale, Ariz.
Money line: Cardinals -290, Panthers +240
Total: 44.5 points
FPI favorite: Cardinals by 5.0, 61.7% to win outright
Denver Broncos -2.5 (-120) at Indianapolis Colts
4:05 p.m. ET, Lucas Oil Stadium, Indianapolis
Money line: Broncos -135, Colts +115
Total: 42.5 points
FPI favorite: Broncos by 2.6, 56.6% to win outright
Philadelphia Eagles -1.5 (+100) at Kansas City Chiefs
4:25 p.m. ET, GEHA Field at Arrowhead Stadium, Kansas City, Mo.
Money line: Eagles -120, Chiefs +100
Total: 46.5 points
FPI favorite: Chiefs by 1.1, 50.9% to win outright
Atlanta Falcons at Minnesota Vikings -4.5 (-110)
8:20 p.m. ET on NBC, U.S. Bank Stadium, Minneapolis
Money line: Vikings -210, Falcons +175
Total: 45.5 points
FPI favorite: Vikings by 4.8, 61.5% to win outright
Monday
Tampa Bay Buccaneers at Houston Texans -1.5 (-115)
7 p.m. ET on ABC/ESPN, NRG Stadium, Houston
Money line: Texans -145, Buccaneers +125
Total: 42.5 points
FPI favorite: Texans by 1.5, 53.9% to win outright
Los Angeles Chargers -3.5 (+105) at Las Vegas Raiders
10 p.m. ET on ESPN, Allegiant Stadium, Las Vegas
Money line: Chargers -190, Raiders +160
Total: 45.5 points
FPI favorite: Chargers by 3.4, 58.4% to win outright