The complete 2025 NFL schedule has been released, and odds are already available for Week 1.
The Philadelphia Eagles will begin their Super Bowl title defense against the Dallas Cowboys in the NFL's season opener on Thursday, Sept. 4.
The Eagles opened as a touchdown favorite at ESPN BET, but it's another NFC East team that has the largest spread of the Week 1 slate. The Washington Commanders opened as a 7.5-point favorite against the New York Giants.
The highest points total in Week 1 is in the Sunday night matchup between the Baltimore Ravens and Buffalo Bills. That number is 51.5, and the Bills opened as 1.5-point favorites at home.
Eleven games have spreads of a field goal or less.
Here's a look at the opening odds for every Week 1 game, as well as other highlights on the schedule that already have spreads.
Odds as of publication time. For most current odds, visit ESPN BET
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The defending Super Bowl champion Philadelphia Eagles will open the regular season against the Dallas Cowboys on Sept. 4.
Thursday, Sept. 4
Dallas Cowboys at Philadelphia Eagles (-7)
8:20 p.m. ET on NBC, Lincoln Financial Field, Philadelphia
Money line: Eagles -300, Cowboys +250
Total: 46.5 points
Friday, Sept. 5
Kansas City Chiefs (-2.5) vs. Los Angeles Chargers
8 p.m. ET on YouTube, Corinthians Arena, São Paulo, Brazil
Money line: Chiefs -155, Chargers +135
Total: 44.5 points
Sunday, Sept. 7
New York Giants at Washington Commanders (-7.5)
1 p.m. ET, Northwest Stadium, Landover, Md.
Money line: Commanders -400, Giants +300
Total: 45.5 points
Tampa Bay Buccaneers (-1.5) at Atlanta Falcons
1 p.m. ET, Mercedes-Benz Stadium, Atlanta
Money line: Buccaneers -135, Falcons +115
Total: 48.5 points
Check out the latest odds and lines for every game on ESPN BET.
Carolina Panthers at Jacksonville Jaguars (-2.5)
1 p.m. ET, EverBank Stadium, Jacksonville, Fla.
Money line: Jaguars -165, Panthers +140
Total: 45.5 points
Miami Dolphins at Indianapolis Colts (-1)
1 p.m. ET, Lucas Oil Stadium, Indianapolis
Money line: Dolphins EVEN, Colts -120
Total: 45.5 points
Las Vegas Raiders at New England Patriots (-2)
1 p.m. ET, Gillette Stadium, Foxborough, Mass.
Money line: Patriots -135, Raiders +115
Total: 43.5 points
Pittsburgh Steelers (-2.5) at New York Jets
1 p.m. ET, MetLife Stadium, East Rutherford, N.J.
Money line: Steelers -155, Jets +135
Total: 39.5 points
Cincinnati Bengals (-5) at Cleveland Browns
1 p.m. ET, Huntington Bank Field, Cleveland
Money line: Bengals -240, Browns +200
Total: 44.5 points
Arizona Cardinals (-4.5) at New Orleans Saints
1 p.m. ET, Caesars Superdome, New Orleans
Money line: Cardinals -195, Saints +165
Total: 41.5 points
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San Francisco 49ers (-1.5) at Seattle Seahawks
4:05 p.m. ET, Lumen Field, Seattle
Money line: 49ers -125, Seahawks +105
Total: 45.5 points
Tennessee Titans at Denver Broncos (-7)
4:05 p.m. ET, Empower Field at Mile High, Denver
Money line: Broncos -320, Titans +260
Total: 41.5 points
Detroit Lions (-1.5) at Green Bay Packers
4:25 p.m. ET, Lambeau Field, Green Bay, Wis.
Money line: Lions -115, Packers -105
Total: 49.5 points
Houston Texans at Los Angeles Rams (-2.5)
4:25 p.m. ET, Sofi Stadium, Inglewood, Calif.
Money line: Rams -145, Texans +125
Total: 46.5 points
Baltimore Ravens at Buffalo Bills (-1.5)
8:20 p.m. ET on NBC, Highmark Stadium, Orchard Park, N.Y.
Money line: Bills -125, Ravens +105
Total: 51.5 points
Monday, Sept. 8
Minnesota Vikings at Chicago Bears (-1)
8:15 p.m. ET on ESPN/ABC, Soldier Field, Chicago
Money line: Bears -110, Vikings -110
Total: 45.5 points
Vikings head coach Kevin O'Connell breaks down how playing in Dublin against the Steelers is a positive thing for the team.
International games
(All games on NFL Network)
Sept. 28, 9:30 a.m. ET: Minnesota Vikings (-1.5, 42.5) vs. Pittsburgh Steelers in Dublin, Ireland
Oct. 5, 9:30 a.m. ET: Vikings (-6.5, 41.5) vs. Cleveland Browns in London
Oct. 12, 9:30 a.m. ET: Denver Broncos (-6, 42.5) vs. New York Jets in London
Oct. 19, 9:30 a.m. ET: Los Angeles Rams (-3.5, 47.5) vs. Jacksonville Jaguars in London
Nov. 9, 9:30 a.m. ET: Atlanta Falcons (-1.5, 44.5) vs. Indianapolis Colts in Berlin
Nov. 16, 9:30 a.m. ET: Washington Commanders (-3, 49.5) vs. Miami Dolphins in Madrid, Spain
Other highlights, with available odds
"Monday Night Football"
Nov. 10, 8:15 p.m. ET on ABC/ESPN: Philadelphia Eagles (-1.5, 45.5) at Green Bay Packers
Thanksgiving Day
Nov. 27, 4:30 p.m. ET on CBS: Kansas City Chiefs (-4, 47.5) at Dallas Cowboys
Black Friday
Nov. 28, 3 p.m. ET on Prime Video: Chicago Bears at Eagles (-7, 46.5)
Week 16's Saturday games
Dec. 20, TBD on FOX: Packers (-1.5, 45.5) at Bears
Dec. 20, TBD on FOX: Eagles (-1.5, 47.5) at Washington Commanders
Christmas Day
Dec. 25, 1 p.m. ET on Netflix: Cowboys at Commanders (-3.5, 51.5)
Dec. 25, 4:30 p.m. ET on Netflix: Detroit Lions (-3, 49.5) at Vikings
Dec. 25, 8:15 p.m. ET on Prime Video: Denver Broncos at Chiefs (-4.5, 44.5)