Lines continue to shift, but the average over/under in Week 4 was right around 50. That would be the highest average weekly over/under in the past 35 seasons (current high is 48.89 in Week 11 of 2018).
Based on the early totals, this week will feature the highest over/unders for Cleveland, Dallas, Seattle, and Green Bay in the past 35 seasons (as far back as our database goes).
Eight games had totals in the 50s as of Wednesday. That would be the most in a single week in the past 35 seasons (the current high is six, in Week 13 of 2018).
Overs are 29-19 this season, tying the highest over percentage through three weeks in the plast 35 seasons (2011 also was 29-19).
Here are more notable odds and ends for Week 4 NFL betting.
Odds listed are from Caesars Sportsbook by William Hill and are subject to change.
Indianapolis Colts (-3, 43) at Chicago Bears, Sunday 1 p.m. ET
The under is 32-21 (60%) in Philip Rivers' starts over the past four seasons, the fourth-lowest rate among 33 QBs with at least 20 starts. But the over has hit in Rivers's past five road starts.
Home underdogs that entered a game 3-0 or better straight up on the season are 17-5 ATS in the Super Bowl era (covered in past six such games).
Nick Foles is 4-12 ATS as starting QB with teams other than the Eagles (20-17-1 ATS as Eagles starting QB, including playoffs). Foles has failed to cover in his past nine starts as starting QB with teams other than the Eagles (0-4 ATS last season with Jacksonville).
New Orleans Saints (-4, 54.5) at Detroit Lions, Sunday, 1 p.m. ET
The Saints are 31-11 ATS (73.8 cover percentage) in the month of October since the start of the 2009 season. They're 12-1 ATS in October from 2016 to '19.
The Saints are an NFL-best 24-9 ATS on the road since the start of the 2016 season. They're 12-4 ATS as road favorites during that time.
The Lions are 2-6 ATS against the Saints with Drew Brees as starting QB.
Arizona Cardinals (-4, 51) at Carolina Panthers, Sunday, 1 p.m. ET
Teddy Bridgewater is 17-4 ATS in his career as an underdog, including the playoffs (10-11 outright).
This is the first time since Week 9 of 2017 that Arizona has been a road favorite.
Carolina has covered all four meetings since 2014.
Jacksonville Jaguars at Cincinnati Bengals (-3, 48.5), Sunday, 1 p.m. ET
The Jaguars are an NFL-best 14-6-1 ATS in games with more than six days of rest since 2011 (not including Week 1 games).
The Jaguars are 3-9 ATS in their past 12 games with a spread of three points or less. They've lost their past five such games both ATS and SU.
The Bengals were 0-3 SU as favorites last season, losing those games by an average of 10 PPG. They were the first team since the 2017 Giants to go winless in a season in games favored (minimum three games).
Cleveland Browns at Dallas Cowboys (-4, 56), Sunday, 1 p.m. ET
This is the highest over/under for either a Cleveland or Dallas game in the Super Bowl era (since 1966).
The Browns are the second team since the start of the 2014 season to fail to cover in at least seven straight road games. The other is the 2016-17 Broncos, who had an eight-game streak.
The Browns are an NFL-worst 31-51-1 ATS as an underdog since the start of the 2015 season, including 1-5 ATS as an underdog over the past two seasons (lost past four).
The Cowboys are off to their first 0-3 ATS start to a season since 1989 (finished 1-15 SU, 6-10 ATS that season). They last started a season 0-4 ATS in 1979 (5-12 ATS that season, including playoffs).
Mike McCarthy is 11-19-1 ATS since the start of the 2017 season. The only coach with a worse record in that time (minimum 20 games coached) is Vance Joseph (10-20-2). McCarthy has failed to cover in his past five games.
Minnesota Vikings at Houston Texans (-4, 54), Sunday, 1 p.m. ET
In games featuring teams 0-3 or worse on the season since 1996, the underdog is 12-6 ATS. The under is 11-7 in those games.
The Vikings are an NFL-best 27-10-1 ATS following a loss in the Mike Zimmer era (since 2014). They're 10-2-1 ATS following a loss dating to the start of the 2018 season.
The Texans are 8-14-2 ATS as a favorite over the past four seasons. In Bill O'Brien's first three seasons as Texans head coach, the team was an NFL-best 15-5-1 ATS as a favorite.
Seattle Seahawks (-6.5, 53.5) at Miami Dolphins, Sunday, 1 p.m. ET
In the past three seasons, Seattle is 7-1-1 ATS in 1 p.m. ET games.
This is the highest over/under in a Seattle game in the Super Bowl era (since 1966). It is the highest total in a Miami game since 1987 when Dan Marino was quarterback (55).
Seattle is 3-0 ATS this season with all three games going over the total.
Los Angeles Chargers at Tampa Bay Buccaneers (-7.5, 43.5), Sunday, 1 p.m. ET
Tom Brady has won eight straight meetings against the Chargers, going 7-1 ATS in that span (since 2006, including playoffs).
Tampa Bay is 6-17-1 ATS as a home favorite since 2014. Los Angeles is 8-4-2 ATS as a road underdog under Anthony Lynn.
Baltimore Ravens (-13.5, 45.5) at Washington Football Team, Sunday, 1 p.m. ET
Baltimore is 36-0 outright as a double-digit favorite in the regular season, the only team never to lose such a game. However, it lost its last game as a double-digit favorite to Tennessee in last year's playoffs.
This is the sixth time in the past 40 seasons a team has been at least a 13-point road favorite within the first four weeks of the season. Each of the previous five won and covered.
Baltimore had won 14 straight regular-season games (going 11-2-1 ATS) before last week's loss to the Chiefs.
New York Giants at Los Angeles Rams (-13, 48.5), Sunday, 4:05 p.m. ET
Three of the past four times New York has been a double-digit underdog, it won the game outright, dating to its Super Bowl XLII win over New England.
Los Angeles is 6-1 ATS as a double-digit favorite under Sean McVay.
New York is 13-3 ATS on the road in its past 16 games (5-2 ATS in Daniel Jones starts).
New York is 8-1 ATS against Los Angeles since 2001.
Los Angeles was 6-1 ATS after a loss last season.
New England Patriots at Kansas City Chiefs (-7, 53), Sunday, 4:25 p.m. ET
New England is 9-2 ATS as an underdog of at least seven points under Bill Belichick. This is just the third time since winning the title in 2001 where New England has been at least a 7-point underdog. The other two games were Week 1 of 2016 after Tom Brady was suspended and Week 17 of 2009 when it was benching its starters midway through the game.
Since 2006, New England is 20-6 ATS as an underdog.
The over is 8-2 in Belichick-Andy Reid matchups.
Patrick Mahomes is 26-12-1 ATS in his career, including the playoffs.
Buffalo Bills (-2.5, 53) at Las Vegas Raiders, Sunday 4:25 p.m. ET
The over is 3-0 in Bills games this season. The over was 18-29-1 in Sean McDermott's first three seasons as Bills head coach.
The over is also 3-0 in Raiders games this season. The over was 62-84-3 for Jon Gruden-coached teams from 2002 to '19 (42%).
Philadelphia Eagles at San Francisco 49ers (-6.5, 45.5), Sunday, 8:20 p.m. ET
San Francisco is 4-17-2 ATS as a home favorite since 2014, including 3-8-2 ATS with Kyle Shanahan as coach (regular season).
This is the second straight season Philadelphia started 0-3 ATS as a favorite in each game. Last year, it upset Green Bay in a prime-time game in Week 4 as a 3.5-point underdog.
Atlanta Falcons at Green Bay Packers (-7.5, 56.5), Monday, 8:15 p.m. ET (ESPN)
The current total of 58 is the highest in any game in the past two seasons. Games with totals of 57 or higher are 21-10-1 to the over in the past 35 seasons and 6-2 in Falcons games, including the playoffs.
All five meetings since 2014 have gone over the total.
Eight straight Atlanta prime-time games have gone under the total.
Atlanta has covered five straight road games dating to last season.
Last season, Atlanta was an underdog of more than seven points twice, and it won both games outright.