49ers look to lock up playoff spot as Rivers tries to keep the Colts in the playoff discussion

— The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night.
Dec 18, 2025, 03:29 pm - AP
2025-12-23T01:15ZOpenSpreadTotalML
San Francisco 49ers49ersSF
(10-4)
(10-4, 6-2 Away)
-5.5
-110
-5.5
-115
o46.5
-102
-270
Indianapolis ColtsColtsIND
(8-6)
(8-6, 6-1 Home)
u45.5
-110
+5.5
-105
u46.5
-118
+220

Season Leaders

SFIND
Mac Jones
2,151
M. JonesQB
201/289, 13 TD, 6 INT
2,151
Passing Yards
Daniel Jones
3,101
D. JonesQBIR
261/384, 19 TD, 8 INT
3,101
Christian McCaffrey
922
C. McCaffreyRB
259 CAR, 9 TD
922
Rushing Yards
Jonathan Taylor
1,443
J. TaylorRB
272 CAR, 16 TD
1,443
Christian McCaffrey
820
C. McCaffreyRB
86 REC, 5 TD
820
Receiving Yards
Alec Pierce
785
A. PierceWRQ
39 REC, 2 TD
785
Clelin Ferrell
4
C. FerrellDE
4
Sacks
Laiatu Latu
6.5
L. LatuDE
6.5
Dee Winters
89
D. WintersLB
89
Tackles
Zaire Franklin
104
Z. FranklinLB
104

Injury Report

San Francisco 49ers
NameStatusEst. Return
Spencer BurfordS. BurfordG
QuestionableAnkle
Dec 22
Sam OkuayinonuS. OkuayinonuDT
QuestionableAnkle
Dec 22
Renardo GreenR. GreenCB
QuestionableNeck
Dec 22
Tatum BethuneT. BethuneLB
QuestionableAnkle
Dec 22
Ricky PearsallR. PearsallWR
QuestionableAnkle
Dec 22
Indianapolis Colts
NameStatusEst. Return
Anthony Richardson Sr.A. Richardson Sr.QB
IR-ROrbital
Dec 28
Anthony GouldA. GouldWR
QuestionableFoot
Dec 22
Alec PierceA. PierceWR
QuestionableAchilles
Dec 22
Sauce GardnerS. GardnerCB
QuestionableCalf
Dec 22
Daniel ScottD. ScottS
IR-RKnee
Dec 22

LAST FIVE GAMES

49ers
DATEOPPRESULT
12/14/25vsTENW37-24
11/30/25@CLEW26-8
11/24/25vsCARW20-9
11/16/25@ARIW41-22
11/9/25vsLARL42-26
Colts
DATEOPPRESULT
12/14/25@SEAL18-16
12/7/25@JAXL36-19
11/30/25vsHOUL20-16
11/23/25@KCL23-20 OT
11/9/25vsATLW31-25 OT
Data is currently unavailable.