San Francisco 49ers @ Indianapolis Colts
Matchup Predictor
43.3
%
SF
56.4
%
IND
According to ESPN Analytics
Game Information
Indianapolis, IN


Season Leaders

1,832
M. JonesQB
168/250, 10 TD, 5 INT
1,832

2,404
D. JonesQB
204/293, 14 TD, 6 INT
2,404

596
C. McCaffreyRB
168 CAR, 4 TD
596

895
J. TaylorRB
157 CAR, 12 TD
895

626
C. McCaffreyRB
61 REC, 4 TD
626

561
M. Pittman Jr.WR
52 REC, 6 TD
561

4
B. HuffDEQ
4

5
L. LatuDE
5

59
D. WintersLBQ
59

62
N. CrossS
62
Injury Report

| Name | Status | Est. Return |
|---|---|---|
QuestionableGroin | Nov 9 | |
QuestionableAnkle | Nov 9 | |
QuestionableHip | Nov 9 | |
QuestionableHamstring | Nov 9 | |
QuestionableKnee | Nov 9 |

| Name | Status | Est. Return |
|---|---|---|
OutNeck | Nov 23 | |
QuestionableKnee | Nov 9 | |
QuestionableGroin | Nov 9 | |
IRConcussion | Nov 23 | |
QuestionableKnee - MCL | Nov 9 |
LAST FIVE GAMES
Data is currently unavailable.
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2025 Standings
National Football Conference
| NFC West | W | L | T | PCT | PF | PA |
|---|---|---|---|---|---|---|
| Seattle | 6 | 2 | 0 | .750 | 231 | 150 |
| Los Angeles | 6 | 2 | 0 | .750 | 209 | 127 |
| San Francisco | 6 | 3 | 0 | .667 | 194 | 188 |
| Arizona | 3 | 5 | 0 | .375 | 180 | 171 |
American Football Conference
| AFC South | W | L | T | PCT | PF | PA |
|---|---|---|---|---|---|---|
| Indianapolis | 7 | 2 | 0 | .778 | 290 | 181 |
| Jacksonville | 5 | 3 | 0 | .625 | 176 | 184 |
| Houston | 3 | 5 | 0 | .375 | 168 | 121 |
| Tennessee | 1 | 8 | 0 | .111 | 130 | 257 |
NFL News

Why Ryan Clark says Kyler Murray has started his last game for Cardinals
Ryan Clark, Bart Scott and Peter Schrager discuss whether Kyler Murray has played his last game for the Cardinals.
11m

Why Bart Scott thinks Jaxon Smith-Njigba is a top MVP candidate
Bart Scott joins "Get Up" to make the argument that Jaxon Smith-Njigba should be in the NFL MVP conversation.
8m

Bart Scott: The Broncos are being held back by QB Bo Nix
Bart Scott, Peter Schrager, Ryan Clark and Joe Fortenbaugh discuss whether the Broncos are real contenders given quarterback Bo Nix's current play.
21m
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