Saturday will be the 36th time that the Ohio State Buckeyes and Michigan Wolverines face off as AP top-15 opponents. Ohio State enters its final regular-season matchup undefeated after its win over Rutgers in Week 13, while Michigan has reeled off five straight wins after its loss to USC in October. ESPN "College GameDay" will start off an exciting day of action, as Desmond Howard, Kirk Herbstreit and crew head to Ann Arbor.
Lone Star State rivals Texas A&M and Texas will face off Friday night. The Aggies make their first visit to Austin since 2010, and only Arch Manning and the Longhorns stand between them and their first unbeaten regular season since 1992.
Georgia will look to clinch a spot in the SEC championship game, and to do so, the Bulldogs, who play in-state rival Georgia Tech in a nonconference game, need either Texas A&M or Alabama to lose. Meanwhile, Alabama just needs a win in the Iron Bowl over Auburn to punch its ticket.
The below section will update after the Tuesday night release of the College Football Playoff's updated rankings.
All times Eastern. For latest lines, go to ESPN BET
No. 6 Ole Miss -7.5 at Mississippi State
Friday, Noon, ABC
Records: Ole Miss 10-1, 2-1 vs. AP teams; Mississippi State 5-6, 1-4 vs. AP teams
Opening line: Ole Miss -7.5, O/U 62.5
Money line: Ole Miss (-260); Mississippi State (+215)
Over/under: 62.5 (O -115, U -105)
FPI projection Ole Miss by 8.7 points with a 78% probability to win game outright
No. 12 Utah -13.5 at Kansas
Friday, Noon, ESPN
Records: Utah 9-2, 2-2 vs. AP teams; Kansas 5-6, 0-1 vs. AP teams
Opening line: Utah -13.5, O/U 58.5
Money line: Off
Over/under: 59.5 (O -115, U -105)
FPI projection Utah by 10.9 points with a 83% probability to win game outright
No. 4 Georgia -12.5 at No. 16 Georgia Tech
Friday, 3:30 p.m., ABC
Records: Georgia 10-1, 3-1 vs. AP teams; Georgia Tech 9-2, 1-0 vs. AP teams
Opening line: Georgia -13.5, O/U 59.5
Money line: Off
Over/under: 59.5 (O -110, U -110)
FPI projection Georgia by 13.9 points with a 87% probability to win game outright
No. 2 Indiana -28.5 at Purdue
Friday, 7:30 p.m., NBC, Peacock
Records: Indiana 11-0, 2-0 vs. AP teams; Purdue 2-9, 0-4 vs. AP teams
Opening line: Indiana -28.5, O/U 52.5
Money line: Off
Over/under: 54.5 (O -105, U -115)
FPI projection Indiana by 28.6 points with a 97% probability to win game outright
No. 3 Texas A&M -2.5 at No. 17 Texas
Friday, 7:30 p.m., ABC
Records: Texas A&M 11-0, 3-0 vs. AP teams; Texas 8-3, 2-2 vs. AP teams
Opening line: Texas A&M -2.5, O/U 51.5
Money line: Off
Over/under: 51.5 (O -110, U -110)
FPI projection Texas by 0.3 points with a 51% probability to win game outright
Arizona -1.5 at No. 25 Arizona State
Friday, 9 p.m., FOX
Records: Arizona 8-3, 1-2 vs. AP teams; Arizona State 8-3, 2-0 vs. AP teams
Opening line: Arizona -1.5, O/U 50.5
Money line: Arizona (-115); Arizona State (-105)
Over/under: 48.5 (O -110, U -110)
FPI projection Arizona State by 0.3 points with a 51% probability to win game outright
No. 1 Ohio State -9.5 at No. 18 Michigan
Saturday, Noon, FOX
Records: Ohio State 11-0, 2-0 vs. AP teams; Michigan 9-2, 0-1 vs. AP teams
Opening line: Ohio State -11.5, O/U 44.5
Money line: Off
Over/under: 45.5 (O -105, U -115)
FPI projection Ohio State by 8.7 points with a 78% probability to win game outright
No. 5 Texas Tech -23.5 at West Virginia
Saturday, Noon, ESPN
Records: Texas Tech 10-1, 2-0 vs. AP teams; West Virginia 4-7, 1-1 vs. AP teams
Line movement alert: Opened Texas Tech -20.5, O/U 52.5
Money line: Texas Tech (-4000); West Virginia (+1300)
Over/under: 53.5 (O -115, U -105)
FPI projection Texas Tech by 18.2 points with a 91% probability to win game outright
No. 13 Miami -6.5 at Pittsburgh
Saturday, Noon, ABC
Records: Miami 9-2, 3-0 vs. AP teams; Pittsburgh 8-3, 2-1 vs. AP teams
Opening line: Miami -6.5, O/U 51.5
Money line: Off
Over/under: 51.5 (O -110, U -110)
FPI projection Miami by 5.3 points with a 70% probability to win game outright
No. 23 Houston at Baylor -1.5
Saturday, Noon, TNT, HBO Max
Records: Houston 8-3, 1-1 vs. AP teams; Baylor 5-6, 1-2 vs. AP teams
Opening line: Baylor -2.5, O/U 60.5
Money line: Houston (EVEN); Baylor (-120)
Over/under: 61.5 (O -105, U -115)
FPI projection Baylor by 1.8 points with a 58% probability to win game outright
UCF at No. 11 BYU -18.5
Saturday, 1 p.m., ESPN2
Records: UCF 5-6, 0-1 vs. AP teams; BYU 10-1, 1-1 vs. AP teams
Opening line: BYU -18.5, O/U 47.5
Money line: Off
Over/under: 47.5 (O -110, U -110)
FPI projection BYU by 21.2 points with a 94% probability to win game outright
No. 7 Oregon -6.5 at Washington
Saturday, 3:30 p.m., CBS
Records: Oregon 10-1, 2-1 vs. AP teams; Washington 8-3, 1-1 vs. AP teams
Opening line: Oregon -7.5, O/U 52.5
Money line: Off
Over/under: 53.5 (O -110, U -110)
FPI projection Oregon by 7.1 points with a 75% probability to win game outright
LSU at No. 8 Oklahoma -10.5
Saturday, 3:30 p.m., ABC
Records: LSU 7-4, 1-4 vs. AP teams; Oklahoma 9-2, 5-1 vs. AP teams
Opening line: Oklahoma -10.5, O/U 38.5
Money line: LSU (+320); Oklahoma (-425)
Over/under: 36.5 (O -115, U -105)
FPI projection Oklahoma by 6.8 points with a 74% probability to win game outright
No. 14 Vanderbilt at No. 20 Tennessee -2.5
Saturday, 3:30 p.m., ESPN
Records: Vanderbilt 9-2, 3-2 vs. AP teams; Tennessee 8-3, 0-3 vs. AP teams
Opening line: Tennessee -3.5, O/U 64.5
Money line: Off
Over/under: 64.5 (O -115, U -105)
FPI projection Tennessee by 1.8 points with a 58% probability to win game outright
No. 22 Missouri -2.5 at Arkansas
Saturday, 3:30 p.m., SEC Network
Records: Missouri 7-4, 0-4 vs. AP teams; Arkansas 2-9, 0-5 vs. AP teams
Opening line: Missouri -2.5, O/U 58.5
Money line: Off
Over/under: 58.5 (O -110, U -110)
FPI projection Missouri by 3.2 points with a 63% probability to win game outright
UCLA at No. 15 USC -20.5
Saturday, 4:30 p.m., NBC
Records: UCLA 3-8, 1-2 vs. AP teams; USC 8-3, 1-3 vs. AP teams
Opening line: USC -20.5, O/U 62.5
Money line: UCLA (+1300); USC (-4000)
Over/under: 60.5 (O -110, U -110)
FPI projection USC by 23.7 points with a 95% probability to win game outright
Virginia Tech at No. 19 Virginia -11.5
Saturday, 7 p.m., ESPN
Records: Virginia Tech 3-8, 0-4 vs. AP teams; Virginia 9-2, 1-0 vs. AP teams
Opening line: Virginia -11.5, O/U 52.5
Money line: Off
Over/under: 52.5 (O -110, U -110)
FPI projection Virginia by 9.6 points with a 80% probability to win game outright
No. 10 Alabama -5.5 at Auburn
Saturday, 7:30 p.m., ABC
Records: Alabama 9-2, 4-1 vs. AP teams; Auburn 5-6, 0-5 vs. AP teams
Opening line: Alabama -3.5, O/U 48.5
Money line: Off
Over/under: 48.5 (O -110, U -110)
FPI projection Alabama by 6.6 points with a 74% probability to win game outright
Northwestern at No. 21 Illinois -6.5
Saturday, 7:30 p.m., FOX
Records: Northwestern 6-5, 0-3 vs. AP teams; Illinois 7-4, 1-2 vs. AP teams
Opening line: Illinois -6.5, O/U 47.5
Money line: Northwestern (+215); Illinois (-260)
Over/under: 47.5 (O -110, U -110)
FPI projection Illinois by 6.3 points with a 73% probability to win game outright
Charlotte at No. 24 Tulane -30.5
Saturday, 7:30 p.m., ESPNU
Records: Charlotte 1-10, 0-1 vs. AP teams; Tulane 9-2, 1-1 vs. AP teams
Opening line: Tulane -29.5, O/U 52.5
Money line: Off
Over/under: 52.5 (O -115, U -105)
FPI projection Tulane by 28.2 points with a 97% probability to win game outright
No. 9 Notre Dame -32.5 at Stanford
Saturday, 10:30 p.m., ESPN
Records: Notre Dame 9-2, 2-2 vs. AP teams; Stanford 4-7, 0-1 vs. AP teams
Opening line: Notre Dame -32.5, O/U 51.5
Money line: Off
Over/under: 52.5 (O -110, U -110)
FPI projection Notre Dame by 24.8 points with a 96% probability to win game outright