Week 4 of the NFL season gets underway with a matchup of NFC West rivals when the Seattle Seahawks visit the Arizona Cardinals on "Thursday Night Football."
Seattle moved to 2-1 with a blowout win over the New Orleans Saints on Sunday, while the Cardinals (2-1) suffered their first loss on a last-second field goal at San Francisco.
The Seahawks, who won both matchups against Arizona last season, are 1.5-point favorites for Thursday's tilt. The two teams will meet again in Week 10 in Seattle.
Here are the odds and trends, plus picks, props and analysis from our experts to help you bet Thursday night's game.
Note: Odds at time of publication. For the latest updates, visit ESPN BET. 
Jump to:
Game picks | Prop bets | Betting trends
Game bets
Moody: The Seahawks match up well with the Cardinals on both sides of the ball. Seattle's defensive front ranks second in pass rush win rate and fourth in run stop win rate, a major edge against Arizona's banged-up offensive line and a backfield missing James Conner. Sam Darnold is thriving in Klint Kubiak's offense and should exploit a Cardinals secondary that has allowed the second-most passing yards per game. The Seahawks have also been excellent on the road under Mike Macdonald, going 8-1 straight up and 5-3 against the spread.
Total points UNDER 43.5 (-110)
Maldonado: Arizona plays at the slowest pace in the league, and both teams lean run-heavy, keeping the clock moving and limiting total plays. Seattle is second in scoring defense and hasn't allowed a rushing touchdown, while Arizona ranks fifth. Neither offense is built for quick hits; Kyler Murray sits near the bottom in air yards per attempt, and Seattle is 31st in dropback rate, leaning more on play-action efficiency than volume. With both defenses strong in the red zone and styles built for long drives, sustained scoring will be hard to come by. Everything points to a grind-it-out divisional game that ends in the low 40s or below.
Notable player props, bets
Sam Darnold to go OVER 29.5 pass attempts (-130)
Walder: The Seahawks are perhaps slightly more pass-heavy than we might have guessed. Last week, Darnold attempted only 18 passes in Seattle's blowout win over the Saints. But context is key: The Seahawks were winning big all game. In fact, after adjusting for that context, the Seahawks were actually the second-heaviest pass rate over expectation team in Week 3. On the season, they're only a shade above average, but that's enough to get my model to make the fair price on this prop -157.
Trey Benson longest rush 15+ yards (even)
Bowen: With Conner out for the season (ankle), Benson takes over as the lead back for the Cardinals. Benson is an explosive runner with the pad level to push through contact, and the uptick in rushing volume puts him in a position to create some big plays versus Seattle.
Jaxon Smith-Njigba to go OVER 85.5 receiving yards (-115)
Moody: Smith-Njigba has seen 10-plus targets in two of three games this season, and his rapport with Darnold is undeniable. JSN has cleared this line in all three games. No team in the league allows more receptions per game to wide receivers than the Cardinals, who also give up the sixth-most receiving yards to the position. Smith-Njigba should stay busy Thursday night.
Cooper Kupp to record 40+ receiving yards (-125)
Walder: Kupp has hit this mark only once in three games as a Seahawk, but my receiving yards model thinks this is an excellent price on a fairly safe bet. Kupp is commanding a decent 24% target rate and is averaging a solid 2.2 yards per route run. That yards per route run number is actually higher than what Kupp averaged with the Rams last year -- and last season his average receiving yards prop line was 66.8! On Thursday, he only needs to reach 40. Plus, what I wrote above about the Seahawks leaning slightly toward the pass relative to expectations helps this prop, too. My receiving yards model makes the fair price here -188.
Trey McBride to score anytime touchdown (+175)
Maldonado: If you're going to roll the dice on one prop in this game, this is the one that checks every box. McBride is the Cardinals' offense. He's running routes on nearly every dropback and commanding one of the highest target shares of any tight end in the league. That usage turns into real scoring opportunities against a Seattle defense that has quietly been a funnel to the position. Nearly a third of the points it has allowed this season has gone to tight ends, the highest rate in the league. Add McBride's track record in this matchup -- 19 receptions on 29 targets in two games last season -- and the path is clear. It's the most logical plus-money swing.
Betting trends
Courtesy of ESPN Research
The Seahawks are 7-0 outright and 6-1 against the spread in their past seven meetings against the Cardinals despite being underdogs in five of those seven games.
Seattle is 0-3 ATS as a road favorite since 2024. Arizona is 8-2 ATS as an underdog since 2024.
The Cardinals are 13-8 ATS after a loss under Jonathan Gannon, including 6-1 ATS in their past seven and 3-0 ATS in their past three.
Murray is 9-14 ATS as a home favorite. Since 2018, the Cardinals are 9-17 ATS as home favorites.