The 2025 women's NCAA basketball tournament is set to tip off as 64 teams look to win it all and make their mark on history. The UCLA Bruins clinched the overall No. 1 seed after a resounding Big 10 tournament win, and spent 12 weeks at No. 1 in the AP poll.
Across the bracket is reigning champion South Carolina, who are looking to repeat history and give head coach Dawn Staley her fourth ring.
USC and Texas round out the one-seeds, and there's a slew of dangerous teams no one wants to play. Paige Bueckers looks to lead UConn to victory in her last year as a Husky, and TCU, Notre Dame and NC State all boast impressive resumes and heaps of talent.
In the wake of stars like Caitlin Clark and Angel Reese leaving the NCAA, there's plenty of new faces and returning veterans ready to make a deep run. JuJu Watkins and Kiki Iriafen will be aiming to win it all for the Trojans, and rookies like UConn's Sarah Strong and Joyce Edwards of the Gamecocks are ready to show off their skills and strengths to the nation.
Here are the pregame lines, spreads and totals from each of the second round matchups. Catch every game from the First Four to the Final Four on ABC, ESPN, ESPN2, ESPNU and ESPNEWS.
Odds are accurate as of publication time. All times eastern. For the latest odds, go to ESPN BET.
Sunday - Round 2
(10) Oregon Ducks
(2) Duke Blue Devils -14.5
Regional 2 in Birmingham, 12 p.m. Cameron Indoor Stadium, Durham, NC
Oregon: 19-11, 10-8 in Big Ten play
Duke: 26-7, 14-4 in ACC play
Odds by ESPN BET
Moneyline: Duke (-2000), Oregon (+1000) Total: 124.5
BPI Projection: Duke by 16.2, straight up: 92.2%
(6) Michigan Wolverines
(3) Notre Dame Fighting Irish -14.5
Regional 3 in Birmingham, 1 p.m. Purcell Pavilion, South Bend, IN
Michigan: 22-10, 11-7 in Big Ten play
Notre Dame: 26-5, 16-2 in ACC play
Odds by ESPN BET
Moneyline: Notre Dame (-1800), Michigan (+900) Total: 153.5
BPI Projection: Notre Dame by 12.8, straight up: 87.5%
(5) Kansas State Wildcats -2.5
(4) Kentucky Wildcats
Regional 4 in Spokane, 2 p.m. Memorial Coliseum (KY), Lexington, KY
Kansas State: 26-7, 13-5 in Big 12 play
Kentucky: 22-7, 11-5 in SEC play
Odds by ESPN BET
Moneyline: Kansas State (-140), Kentucky (+120) Total: 140.5
BPI Projection: Kansas State by 3.2, straight up: 61.8%
(9) Indiana Hoosiers
(1) South Carolina Gamecocks -22.5
Regional 2 in Birmingham, 3 p.m. Colonial Life Arena, Columbia, SC
Indiana: 19-12, 10-8 in Big Ten play
South Carolina: 30-3, 15-1 in SEC play
Odds by ESPN BET
Moneyline: South Carolina (-50000), Indiana (+3500) Total: 136.5
BPI Projection: South Carolina by 20.1, straight up: 95.6%
(5) Ole Miss Rebels
(4) Baylor Bears -3.5
Regional 1 in Spokane, 4 p.m. Foster Pavilion, Waco, TX
Ole Miss: 20-10, 10-6 in SEC play
Baylor: 28-7, 15-3 in Big 12 play
Odds by ESPN BET
Moneyline: Baylor (-150), Ole Miss (+125) Total: 136.5
BPI Projection: Baylor by 3.7, straight up: 63.9%
(7) Louisville Cardinals
(2) TCU Horned Frogs -12.5
Regional 3 in Birmingham, 6 p.m. Schollmaier Arena, Fort Worth, TX
Louisville: 21-10, 13-5 in ACC play
TCU: 31-3, 16-2 in Big 12 play
Odds by ESPN BET
Moneyline: TCU (-1200), Louisville (+700) Total: 136.5
BPI Projection: TCU by 6.9, straight up: 74.2%
(5) Tennessee Lady Volunteers -1.5
(4) Ohio State Buckeyes
Regional 3 in Birmingham, 8 p.m. Schottenstein Center, Columbus, OH
Tennessee: 22-9, 8-8 in SEC play
Ohio State: 25-6, 13-5 in Big Ten play
Odds by ESPN BET
Moneyline: Tennessee (-120), Ohio State (+EVEN) Total: 162.5
BPI Projection: Ohio State by 1.9, straight up: 57.3%
(8) Richmond Spiders
(1) UCLA Bruins
Regional 1 in Spokane, 10 p.m. Pauley Pavilion, Los Angeles, CA
Richmond: 27-6, 17-1 in A-10 play
UCLA: 30-2, 15-2 in Big Ten play
Betting lines TBD
BPI Projection: UCLA by 21, straight up: 96.1%
Monday - Round 2
(7) Michigan State Spartans
(2) NC State Wolfpack -6.5
Regional 1 in Spokane, 12 p.m. Reynolds Coliseum, Raleigh, NC
Michigan State: 21-9, 11-7 in Big Ten play
NC State: 26-6, 16-2 in ACC play
Odds by ESPN BET
Moneyline: NC State (-270), Michigan State (+220) Total: 153.5
BPI Projection: NC State by 3.4, straight up: 62.5%
(8) Illinois Fighting Illini
(1) Texas Longhorns
Regional 3 in Birmingham, 2 p.m. Moody Center, Austin, TX
Illinois: 21-9, 11-7 in Big Ten play
Texas: 31-3, 15-1 in SEC play
Betting lines TBD
BPI Projection: Texas by 17.2, straight up: 93.2%
(6) Iowa Hawkeyes
(3) Oklahoma Sooners -4.5
Regional 4 in Spokane, 4 p.m. Lloyd Noble Center, Norman, OK
Iowa: 22-10, 10-8 in Big Ten play
Oklahoma: 25-7, 11-5 in SEC play
Odds by ESPN BET
Moneyline: Oklahoma (-185), Iowa (+155) Total: 158.5
BPI Projection: Oklahoma by 6.4, straight up: 72.7%
(5) Alabama Crimson Tide
(4) Maryland Terrapins
Regional 2 in Birmingham, 5 p.m. XFINITY Center, College Park, MD
Alabama: 23-8, 10-6 in SEC play
Maryland: 23-7, 13-5 in Big Ten play
Odds by ESPN BET
Moneyline: Alabama (-110), Maryland (-110) Total: 153.5
BPI Projection: Maryland by 0.7, straight up: 52.7%
(6) Florida State Seminoles
(3) LSU Tigers
Regional 1 in Spokane, 6 p.m. Pete Maravich Assembly Center, Baton Rouge, LA
Florida State: 23-8, 13-5 in ACC play
LSU: 30-5, 12-4 in SEC play
Betting lines TBD
BPI Projection: LSU by 9.3, straight up: 80.5%
(6) West Virginia Mountaineers -1.5
(3) North Carolina Tar Heels
Regional 4 in Spokane, 7 p.m. Carmichael Arena, Chapel Hill, NC
West Virginia: 24-7, 13-5 in Big 12 play
North Carolina: 27-7, 13-5 in ACC play
Odds by ESPN BET
Moneyline: West Virginia (-120), North Carolina (+100) Total: 126.5
BPI Projection: West Virginia by 1.3, straight up: 54.9%
(10) South Dakota State Jackrabbits
(2) UConn Huskies
Regional 4 in Spokane, 8 p.m. Gampel Pavilion, Storrs, CT
South Dakota State: 29-3, 16-0 in Summit play
Uconn: 31-3, 18-0 in Big East play
Betting lines TBD
BPI Projection: Uconn by 27.9, straight up: 98.6%
(9) Mississippi State Bulldogs
(1) USC Trojans -17.5
Regional 4 in Spokane, 10 p.m. Galen Center, Los Angeles, CA
Mississippi State: 21-11, 7-9 in SEC play
USC: 28-3, 16-1 in Big Ten play
Odds by ESPN BET
Moneyline: USC (-4000), Mississippi State (+1300) Total: 147.5
BPI Projection: USC by 16, straight up: 91.9%