The biggest matchup of the weekend is a Big Ten clash on the West Coast, with the USC Trojans challenging the Oregon Ducks. "College GameDay" will be making its second visit of the season to Eugene, Oregon, to start a busy Saturday of college football.
Texas A&M survived a scare against South Carolina before bouncing back to win. The Aggies will face FCS Samford in College Station, Texas. Elsewhere in the SEC, there are only four intraconference matchups, including Kentucky at Vanderbilt, Arkansas against Texas, Tennessee against rival Florida, and Missouri vs. Oklahoma.
Ohio State is still undefeated, and the Buckeyes will begin Saturday's action when they kick off against Rutgers at noon ET. Notre Dame, the highest-ranked two-loss team, will welcome ACC opponent Syracuse to South Bend, Indiana.
All times Eastern. For latest lines, go to ESPN BET
Rutgers at No. 1 Ohio State -32.5
Saturday, Noon, FOX
Records: Rutgers 5-5, 0-1 vs. AP teams; Ohio State 10-0, 2-0 vs. AP teams
Opening Line: Ohio State -33.5
Money line: Rutgers (+3500); Ohio State (-50000)
Over/Under: Off
FPI Projection Ohio State by 28.3 points with a 97% probability to win game outright
Samford Bulldogs at No. 3 Texas A&M
Saturday, Noon, SECN+
Records: Samford 1-10 (8th in Southern); Texas A&M 10-0, 3-0 vs. AP teams
No line posted
FPI Projection Texas A&M by 56.1 points with a >99% probability to win game outright
No. 22 Missouri at No. 8 Oklahoma -6.5
Saturday, Noon, ABC
Records: Missouri 7-3, 0-3 vs. AP teams; Oklahoma 8-2, 4-1 vs. AP teams
Line Movement Alert: Opened Oklahoma -9.5, O/U 42.5
Money line: Missouri (+210); Oklahoma (-250)
Over/Under: 42.5 (O -105, U -115)
FPI Projection Oklahoma by 3.5 points with a 64% probability to win game outright
No. 13 Miami at Virginia Tech
Saturday, Noon, ESPN
Records: Miami 8-2, 3-0 vs. AP teams; Virginia Tech 3-7, 0-3 vs. AP teams
Money line: Miami (-1200); Oklahoma (+700)
Over/Under: 48.5 (O -110, U -110)
FPI Projection Miami by 16.8 points with a 90% probability to win game outright
Charlotte at No. 4 Georgia -44.5
Saturday, 12:45 p.m., SEC Network
Records: Charlotte 1-9, 0-0 vs. AP teams; Georgia 9-1, 3-1 vs. AP teams
Opening Line: Georgia -44.5, O/U 55.5
Money line: Off
Over/Under: 53.5 (O -110, U -110)
FPI Projection Georgia by 50.3 points with a >99% probability to win game outright
Eastern Illinois Panthers at No. 10 Alabama
Saturday, 2 p.m., SECN+
Records: Eastern Illinois 3-8 (8th in OVC/Big South); Alabama 8-2, 4-1 vs. AP teams
No line posted
FPI Projection Alabama by 57.7 points with a >99% probability to win game outright
No. 15 USC at No. 7 Oregon -10.5
Saturday, 3:30 p.m., CBS
Records: USC 8-2, 1-2 vs. AP teams; Oregon 9-1, 1-1 vs. AP teams
Opening Line: Oregon -8.5, O/U 55.5
Money line: USC (+300); Oregon (-400)
Over/Under: 59.5 (O -105, U -115)
FPI Projection Oregon by 6 points with a 72% probability to win game outright
Syracuse at No. 9 Notre Dame -35.5
Saturday, 3:30 p.m., NBC, Peacock
Records: Syracuse 3-7, 0-3 vs. AP teams; Notre Dame 8-2, 2-2 vs. AP teams
Opening Line: Notre Dame -35.5, O/U 51.5
Money line: Off
Over/Under: 50.5 (O -115, U -105)
FPI Projection Notre Dame by 30.2 points with a 97% probability to win game outright
Kentucky at No. 14 Vanderbilt -8.5
Saturday, 3:30 p.m., ESPN
Records: Kentucky 5-5, 0-4 vs. AP teams; Vanderbilt 8-2, 3-2 vs. AP teams
Opening Line: Vanderbilt -10.5, O/U 52.5
Money line: Kentucky (+280); Vanderbilt (-360)
Over/Under: 54.5 (O -120, U -110)
FPI Projection Vanderbilt by 7.7 points with a 77% probability to win game outright
Arkansas at No. 17 Texas -8.5
Saturday, 3:30 p.m., ABC
Records: Arkansas 2-8, 0-4 vs. AP teams; Texas 7-3, 2-2 vs. AP teams
Opening Line: Texas -10.5, O/U 56.5
Money line: Arkansas (+260); Texas (-320)
Over/Under: 58.5 (O -105, U -115)
FPI Projection Texas by 11.3 points with a 83% probability to win game outright
No. 24 Tulane -9.5 at Temple
Saturday, 3:45 p.m., ESPNU
Records: Tulane 8-2, 1-1 vs. AP teams; Temple 5-5, 0-2 vs. AP teams
Opening Line: Tulane -8.5, O/U 54.5
Money line: Tulane (-380); Temple (+290)
Over/Under: 54.5 (O EVEN, U -120)
FPI Projection Tulane by 4.4 points with a 66% probability to win game outright
Kansas State at No. 12 Utah -17.5
Saturday, 4 p.m., ESPN2
Records: Kansas State 5-5, 0-2 vs. AP teams; Utah 8-2, 2-2 vs. AP teams
Opening Line: Utah -17.5, O/U 52.5
Money line: Kansas State (+550); Utah (-900)
Over/Under: 51.5 (O -110, U -110)
FPI Projection Utah by 15.4 points with a 89% probability to win game outright
No. 18 Michigan -14.5 at Maryland
Saturday, 4 p.m., BTN
Records: Michigan 8-2, 0-1 vs. AP teams; Maryland 4-6, 0-1 vs. AP teams
Opening Line: Michigan -13.5, O/U 45.5
Money line: Michigan (-800); Maryland (+500)
Over/Under: 46.5 (O -105, U -115)
FPI Projection Michigan by 10.6 points with a 82% probability to win game outright
TCU at No. 23 Houston -1.5
Saturday, 4 p.m., FOX
Records: TCU 6-4, 0-1 vs. AP teams; Houston 8-2, 1-1 vs. AP teams
Opening Line: Houston -2.5, O/U 54.5
Money line: TCU (+EVEN); Houston (-120)
Over/Under: 54.5 (O -105, U -105)
FPI Projection TCU by 0.8 points with a 53% probability to win game outright
Pittsburgh at No. 16 Georgia Tech -2.5
Saturday, 7 p.m., ESPN
Records: Pittsburgh 7-3, 1-1 vs. AP teams; Georgia Tech 9-1, 1-0 vs. AP teams
Opening Line: Georgia Tech -2.5, O/U 61.5
Money line: Pittsburgh (+115); Georgia Tech (-135)
Over/Under: 61.5 (O -105, U -115)
FPI Projection Georgia Tech by 1.6 points with a 57% probability to win game outright
No. 20 Tennessee -4.5 at Florida
Saturday, 7:30 p.m., ABC
Records: Tennessee 7-3, 0-3 vs. AP teams; Florida 3-7, 1-5 vs. AP teams
Opening Line: Tennessee -3.5, O/U 57.5
Money line: Tennessee (-190); Florida (+160)
Over/Under: 57.5 (O -110, U -110)
FPI Projection Tennessee by 3.8 points with a 65% probability to win game outright
No. 21 Illinois -8.5 at Wisconsin
Saturday, 7:30 p.m., BTN
Records: Illinois 7-3, 1-2 vs. AP teams; Wisconsin 3-7, 1-5 vs. AP teams
Opening Line: Illinois -9.5, O/U 42.5
Money line: Illinois (-380); Wisconsin (+290)
Over/Under: 41.5 (O -110, U -110)
FPI Projection Illinois by 5.8 points with a 72% probability to win game outright
No. 11 BYU -2.5 at Cincinnati
Saturday, 8 p.m., FOX
Records: BYU 9-1, 1-1 vs. AP teams; Cincinnati 7-3, 1-1 vs. AP teams
Opening Line: BYU -2.5, O/U 53.5
Money line: BYU (-135); Cincinnati (+115)
Over/Under: 55.5 (O -115, U -105)
FPI Projection BYU by 4.7 points with a 68% probability to win game outright
No. 25 Arizona State -7.5 at Colorado
Saturday, 8 p.m., ESPN2
Records: Arizona State 7-3, 2-0 vs. AP teams; Colorado 3-7, 1-1 vs. AP teams
Opening Line: Arizona State -8.5, O/U 48.5
Money line: Arizona State (-290); Colorado (+240)
Over/Under: 46.5 (O -115, U -105)
FPI Projection Arizona State by 3.4 points with a 63% probability to win game outright