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Should Louisville be on high alert against Boston College?

Lamar Jackson scored just one touchdown and threw two interceptions against Boston College last season. Andy Lyons/Getty Images

Does Louisville have anything to worry about this week at Boston College? Can Pittsburgh and Virginia win on the road? Let's take a look at the teams on Upset Watch for Week 10:

No. 5 Louisville (7-1, 5-1) at Boston College (4-4, 1-4), noon, ESPN2. Line: Louisville by 24. The Cards struggled last week against Virginia and needed a last-second comeback to win. Now, they hit the road again as heavy favorites against a team that presented all sorts of issues a year ago. For those who have erased this game from their memories, here is a quick refresher: The teams combined for 32 tackles for loss and 15 sacks in Louisville's rugged 17-14 victory. Lamar Jackson ended up with just one total touchdown and two interceptions as the Eagles totally shut him down. Jackson is much better this year than he was last, but Boston College might have some confidence going into this game after winning its first ACC contest since 2014. Jackson said his team was not focused against Virginia. Will that focus return despite playing a team that sits near the bottom of the Atlantic?

Pittsburgh (5-3, 2-2) at Miami (4-4, 1-3), 12:30 p.m., ACC Network. Line: Miami by 3. It does seem surprising Miami is the favorite in this game, considering the Hurricanes have lost four straight games, and all three of Pitt's losses have been by a touchdown or less. Pittsburgh presents major challenges for Miami up front. The Hurricanes are really struggling on the offensive line, and that can't be good with Ejuan Price coming to town. Price is tied for second in the nation with nine sacks this season, and chances are he will pick up a few more Saturday. Though Pitt has struggled in the secondary, Miami has struggled to get its passing game going and that could be yet another advantage for the Panthers.

Virginia (2-6, 1-3) at Wake Forest (5-3, 2-2), 3 p.m., ACC Network. Line: Wake Forest by 3. Wake Forest starting quarterback Kendall Hinton has not been cleared to play yet, and it is becoming clear the Deacs could use him. They faltered last week against Army and now face a Virginia team that has made major strides since its opening week loss to Richmond. The Cavaliers nearly upset Louisville last week and have one of the best linebackers in the nation in Micah Kiser and an improving pass rush (five sacks last week). And it also should be noted that Virginia generally has success in Winston-Salem, winning 16 of 20 meetings.