Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of LaLiga fixtures.
And as you plan your fantasy team for the next gameweek, check out the predicted XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All predicted XIs and injury news powered by Rotowire and subject to updates.)
Real Madrid v Celta Vigo
Santiago Bernabéu, Madrid
Line: RMA -270, 1 p.m. GMT / 8 a.m. ET
Latest Real Madrid team news
Expected Lineup:
GK Thibaut Courtois
LB Fran García | CB Raúl Asencio | CB Aurélien Tchouaméni | RB Lucas Vázquez
DM Dani Ceballos
CM Jude Bellingham | CM Federico Valverde
FWL Vinícius Jr. | ST Kylian Mbappé | FWR Rodrygo
Player availability updates:
David Alaba, D, knee, OUT, estimated return May. 25
Eduardo Camavinga, M, groin, OUT, estimated return May. 25
Dani Carvajal, D, knee, OUT, estimated return May. 25
Ferland Mendy, D, quadriceps, OUT, estimated return May. 25
Éder Militão, D, knee, OUT, estimated return Aug. 1
Antonio Rüdiger, D, knee, OUT, estimated return Jul. 1
Latest Celta Vigo team news
Expected Lineup:
GK Vicente Guaita
CB Carlos Domínguez | CB Yoel Lago | CB Marcos Alonso
LM Óscar Mingueza | CM Fran Beltrán | CM Damián Rodríguez | RM Hugo Álvarez
FWL Alfonso González | ST Borja Iglesias | FWR Fernando López
Player availability updates:
Jones El-Abdellaoui, F, undisclosed, OUT, estimated return May. 11
Carl Starfelt, D, hamstring, OUT, estimated return Jun. 15
Sevilla v Leganés
Ramón Sánchez-Pizjuán, Sevilla
Line: SEV -125, 3:15 p.m. GMT / 10:15 a.m. ET
Latest Sevilla team news
Expected Lineup:
GK Ørjan Nyland
LB Adrià Pedrosa | CB Loïc Badé | CB Enrique Salas | RB José Ángel Carmona
DM Lucien Agoumé | DM Saúl Ñíguez
LW Diego Hormigo | AM Djibril Sow | RW Juanlu Sanchez
ST Isaac Romero
Player availability updates:
Akor Adams, F, thigh, OUT, estimated return Aug. 1
Albert Sambi Lokonga, M, hamstring, DOUBT
Tanguy Nianzou, D, thigh, OUT, estimated return May. 10
Ruben Vargas, F/M, hamstring, OUT, estimated return May. 14
Latest Leganés team news
Expected Lineup:
GK Marko Dmitrovic
LB Javi Hernández | CB Sergio González | CB Jorge | RB Valentin Rosier
DM Renato Tapia
LM Raba | CM Óscar Rodríguez | CM Yvan Neyou | RM Juan Cruz
ST Diego Garcia
Player availability updates:
Adrià Altimira, D, suspension, due back May. 11
Borna Barisic, D, knee, OUT, estimated return Aug. 1
Seydouba Cissé, M, suspension, due back May. 11
Enric Franquesa, D, knee, OUT, estimated return Sep. 1
Matija Nastasic, D, strain, DOUBT
Espanyol v Real Betis
RCDE Stadium, Barcelona
Line: BET +130, 5:30 p.m. GMT / 12:30 p.m. ET
Latest Espanyol team news
Expected Lineup:
GK Joan García
LB Carlos Romero | CB Leandro Cabrera | CB Marash Kumbulla | RB Omar El Hilali
DM Urko Gonzalez de Zarate | DM Alex Král
LW Javier Puado | AM Edu Expósito | RW Antoniu Roca
ST Roberto Fernández
Player availability updates:
José Gragera, M, foot, DOUBT
Brian Oliván, D, calf, DOUBT
Latest Real Betis team news
Expected Lineup:
GK Adrián
LB Romain Perraud | CB Marc Bartra | CB Natan | RB Youssouf Sabaly
DM Pablo Fornals | DM Johnny Cardoso
LW Jesús Rodriguez | AM Isco | RW Antony
ST Cucho Hernandez
Player availability updates:
Chimy Ávila, F, thigh, OUT, estimated return Jul. 1
Diego Llorente, D, hamstring, OUT, estimated return Aug. 1
Marc Roca, M, foot, OUT, estimated return May. 11
Aitor Ruibal, D, suspension, due back May. 11
Real Sociedad v Athletic Club
Reale Arena, San Sebastián
Line: RSO +140, 8 p.m. GMT / 3 p.m. ET
Latest Real Sociedad team news
Expected Lineup:
GK Álex Remiro
LB Javi López | CB Nayef Aguerd | CB Jon Martín | RB Jon Aramburu
DM Martín Zubimendi
LM Sergio Gómez | CM Pablo Marín | CM Brais Méndez | RM Takefusa Kubo
ST Mikel Oyarzabal
Player availability updates:
Nayef Aguerd, D, knee, DOUBT
Álvaro Odriozola, D, undisclosed, DOUBT
Orri Óskarsson, F, hamstring, OUT, estimated return Jun. 1
Arsen Zakharyan, M, thigh, OUT, estimated return May. 18
Igor Zubeldia, D, groin, OUT, estimated return May. 10
Latest Athletic Club team news
Expected Lineup:
GK Unai Simón
LB Yuri Berchiche | CB Yeray | CB Dani Vivian | RB Óscar de Marcos
DM Mikel Jauregizar | DM Iñigo Ruiz de Galarreta
LW Nico Williams | AM Álex Berenguer | RW Iñaki Williams
ST Gorka Guruzeta
Player availability updates:
Oihan Sancet, F/M, leg, OUT, estimated return May. 11
Girona v Mallorca
Municipal de Montilivi, Girona
Line: GIR +105, 8 p.m. GMT / 3 p.m. ET
Latest Girona team news
Expected Lineup:
GK Paulo Gazzaniga
CB Daley Blind | CB Ladislav Krejcí | CB David López
LM Miguel Gutiérrez | CM Yangel Herrera | CM Arthur | RM Arnau Martínez
FWL Yáser Asprilla | ST Arnaut Danjuma | FWR Viktor Tsygankov
Player availability updates:
Ricard Artero, M, ankle, OUT, estimated return Aug. 1
Bryan Gil, F/M, knee, OUT, estimated return Aug. 1
Abel Ruiz, F, hamstring, DOUBT
Latest Mallorca team news
Expected Lineup:
GK Dominik Greif
LB Johan Mojica | CB José Copete | CB Antonio Raíllo | CB Martin Valjent | RB Pablo Maffeo
LM Sergi Darder | CM Samú Costa | CM Omar Mascarell | RM Dani Rodríguez
ST Cyle Larin
Player availability updates:
Takuma Asano, F, hamstring, DOUBT
Manu Morlanes, M, hamstring, OUT, estimated return May. 10
Vedat Muriqi, F, hamstring, DOUBT
Robert Navarro, M, hamstring, DOUBT
Abdón Prats, F, calf, OUT, estimated return May. 25