Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of LaLiga fixtures.
And as you plan your fantasy team for the next gameweek, check out the predicted XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All predicted XIs and injury news powered by Rotowire and subject to updates.)
Leganés v Barcelona
Butarque, Leganés, Madrid
Saturday, 8 p.m. GMT / 3 p.m. ET
Latest Leganés team news
Expected Lineup:
GK Marko Dmitrovic
LB Javi Hernández | CB Sergio González | CB Matija Nastasic | CB Renato Tapia | RB Valentin Rosier
DM Yvan Neyou
CM Óscar Rodríguez | CM Seydouba Cissé
ST Raba | ST Juan Cruz
Player availability updates:
Borna Barisic, D, knee, OUT, estimated return Aug. 1
Enric Franquesa, D, knee, OUT, estimated return Sep. 1
Latest Barcelona team news
Expected Lineup:
GK Wojciech Szczesny
LB Gerard Martín | CB Ronald Araújo | CB Iñigo Martínez | RB Jules Koundé
DM Eric García
CM Pedri | CM Gavi
FWL Raphinha | ST Ferran Torres | FWR Lamine Yamal
Player availability updates:
Marc Bernal, M/D, knee, OUT, estimated return Sep. 1
Marc Casadó, M, knee, OUT, estimated return May. 18
Dani Olmo, F/M, groin, OUT, estimated return Apr. 19
Marc-André ter Stegen, G, knee, OUT, estimated return May. 4
Osasuna v Girona
El Sadar, Pamplona
Sunday, 1 p.m. GMT / 8 a.m. ET
Latest Osasuna team news
Expected Lineup:
GK Sergio Herrera
LB Abel Bretones | CB Flavien-Enzo Boyomo | CB Alejandro Catena | CB Jorge Herrando | RB Jesús Areso
CM Jon Moncayola | CM Lucas Torró
AM Rubén García | AM Aimar Oroz
ST Ante Budimir
Player availability updates:
Bryan Zaragoza, M, hamstring, DOUBT
Latest Girona team news
Expected Lineup:
GK Paulo Gazzaniga
LB Miguel Gutiérrez | CB Daley Blind | CB Ladislav Krejcí | RB Arnau Martínez
DM Yangel Herrera | DM Arthur
LW Arnaut Danjuma | AM Viktor Tsygankov | RW Yáser Asprilla
ST Abel Ruiz
Player availability updates:
Ricard Artero, M, ankle, OUT, estimated return Aug. 1
Bryan Gil, F/M, knee, OUT, estimated return Aug. 1
Iván Martín, M, hamstring, DOUBT
Alavés v Real Madrid
Mendizorroza, Vitoria-Gasteiz
Sunday, 3:15 p.m. GMT / 10:15 a.m. ET
Latest Alavés team news
Expected Lineup:
GK Adrián Pica
LB Manu Sánchez | CB Abdel Abqar | CB Santiago Mouriño | RB Nahuel Tenaglia
LM Carles Aleñá | CM Antonio Blanco | CM Joan Jordán | RM Carlos Vicente
ST Enrique García | ST Carlos Martín
Player availability updates:
Tomás Conechny, M, suspension, due back Apr. 20
Jon Guridi, M, suspension, due back Apr. 20
Antonio Sivera, G, suspension, due back Apr. 20
Latest Real Madrid team news
Expected Lineup:
GK Thibaut Courtois
LB Fran García | CB Raúl Asencio | CB Aurélien Tchouaméni | RB Lucas Vázquez
DM Eduardo Camavinga
CM Jude Bellingham | CM Federico Valverde
FWL Vinícius Jr. | ST Kylian Mbappé | FWR Rodrygo
Player availability updates:
Dani Carvajal, D, knee, OUT, estimated return May. 25
Dani Ceballos, M, leg, DOUBT
Ferland Mendy, D, hamstring, DOUBT
Éder Militão, D, knee, OUT, estimated return Aug. 1
Real Betis v Villarreal
Benito Villamarín, Sevilla
Sunday, 5:30 p.m. GMT / 12:30 p.m. ET
Latest Real Betis team news
Expected Lineup:
GK Adrián
LB Romain Perraud | CB Marc Bartra | CB Diego Llorente | RB Aitor Ruibal
DM Sergi Altimira | DM Johnny Cardoso
LW Giovani Lo Celso | AM Isco | RW Antony
ST Cucho Hernandez
Player availability updates:
Abde Ezzalzouli, F/M, ankle, OUT, estimated return Apr. 24
Ángel Ortiz, D, ankle, DOUBT
Latest Villarreal team news
Expected Lineup:
GK Luiz Júnior
LB Sergi Cardona | CB Logan Costa | CB Juan Foyth | RB Kiko Femenia
LM Álex Baena | CM Santi Comesaña | CM Dani Parejo | RM Yeremy Pino
ST Thierno Barry | ST Ayoze Pérez
Player availability updates:
Ilias Akhomach, F, knee, OUT, estimated return Jul. 1
Raúl Albiol, D, undisclosed, DOUBT
Tajon Buchanan, M, ankle, DOUBT
Pape Gueye, M, suspension, due back Apr. 20
Nicolas Pépé, F/M, undisclosed, DOUBT
Athletic Club v Rayo Vallecano
San Mamés, Bilbao
Sunday, 8 p.m. GMT / 3 p.m. ET
Latest Athletic Club team news
Expected Lineup:
GK Unai Simón
LB Adama Boiro | CB Unai Núñez | CB Aitor Paredes | RB Andoni Gorosabel
DM Beñat Prados | DM Mikel Vesga
LW Álex Berenguer | AM Unai Gómez | RW Iñaki Williams
ST Gorka Guruzeta
Player availability updates:
Yuri Berchiche, D, leg, OUT, estimated return Apr. 17
Latest Rayo Vallecano team news
Expected Lineup:
GK Augusto Batalla
LB Pep Chavarría | CB Aridane Hernández | CB Florian Lejeune | RB Andrei Ratiu
DM Pathé Ciss | DM Pedro Díaz
LW Álvaro García | AM Isi Palazón | RW Jorge de Frutos
ST Randy Nteka
Player availability updates:
Sergio Camello, F, toe, DOUBT
Abdul Mumin, D, knee, OUT, estimated return Aug. 1
Atlético Madrid v Real Valladolid
Riyadh Air Metropolitano, Madrid
Monday, 8 p.m. GMT / 3 p.m. ET
Latest Atlético Madrid team news
Expected Lineup:
GK Jan Oblak
LB Javi Galán | CB José María Giménez | CB Clément Lenglet | RB Marcos Llorente
LM Conor Gallagher | CM Pablo Barrios | CM Koke | RM Giuliano Simeone
ST Julián Álvarez | ST Antoine Griezmann
Player availability updates:
Ángel Correa, F/M, suspension, due back Apr. 20
Rodrigo De Paul, M, thigh, DOUBT
Samuel Lino, M/D, strain, DOUBT
Latest Real Valladolid team news
Expected Lineup:
GK André Ferreira
LB Adam Aznou | CB Joseph Aidoo | CB Javi Sánchez | CB David Torres | RB Antonio Candela
LM Raúl Moro | CM Tamás Nikitscher | CM Florian Grillitsch | RM Anuar
ST Marcos André
Player availability updates:
Karl Hein, G, undisclosed, OUT, estimated return May. 4
Mario Martín, M, suspension, due back Apr. 20