Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Ipswich Town v Brighton & Hove Albion
Portman Road
Thursday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Ipswich Town team news
Expected Lineup:
GK Christian Walton
LB Leif Davis | CB Jacob Greaves | CB Dara O'Shea | CB Luke Woolfenden | RB Ben Johnson
LM Nathan Broadhead | CM Jens Cajuste | CM Sam Morsy | RM Wes Burns
ST Liam Delap
Injury/suspension updates:
Conor Chaplin, F/M, knee, OUT, estimated return Jan. 25
Omari Hutchinson, F/M, groin, DOUBT
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Sammie Szmodics, F/M, strain, OUT, estimated return Feb. 1
Axel Tuanzebe, D, hamstring, OUT, estimated return Feb. 1
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Joël Veltman
DM Yasin Ayari | DM Carlos Baleba
LW Kaoru Mitoma | AM Julio Enciso | RW Brajan Gruda
ST Danny Welbeck
Injury/suspension updates:
Lewis Dunk, D, calf, DOUBT
Evan Ferguson, F, ankle, OUT, estimated return Jan. 25
Jack Hinshelwood, M/D, knee, DOUBT
Igor Julio, D, hamstring, OUT, estimated return Jun. 1
João Pedro, F/M, ankle, DOUBT
Ferdi Kadioglu, M/D, toe, OUT, estimated return Feb. 14
James Milner, M/D, hamstring, OUT, estimated return Jan. 25
Yankuba Minteh, F, hamstring, DOUBT
Georginio Rutter, F, hamstring, DOUBT
Mats Wieffer, M, undisclosed, OUT, estimated return Jan. 25
Manchester United v Southampton
Old Trafford
Thursday, 8 p.m. GMT / 3 p.m. ET
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Harry Maguire | CB Lisandro Martínez
LM Tyrell Malacia | CM Kobbie Mainoo | CM Manuel Ugarte | RM Noussair Mazraoui
AM Amad Diallo | AM Bruno Fernandes
ST Rasmus Højlund
Injury/suspension updates:
Diogo Dalot, M/D, suspension, due back Jan. 19
Jonny Evans, D, undisclosed, OUT, estimated return Jan. 19
Victor Lindelöf, D, concussion, OUT, estimated return Jan. 19
Harry Maguire, D, illness, DOUBT
Mason Mount, F/M, strain, OUT, estimated return Feb. 2
Marcus Rashford, F, illness, DOUBT
Luke Shaw, D, calf, OUT, estimated return Jan. 26
Latest Southampton team news
Expected Lineup:
GK Aaron Ramsdale
CB Jan Bednarek | CB Taylor Harwood-Bellis | CB Nathan Wood
LM Kyle Walker-Peters | CM Flynn Downes | CM Lesley Ugochukwu | RM Yukinari Sugawara
AM Tyler Dibling | AM Mateus Fernandes
ST Paul Onuachu
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Feb. 15
Flynn Downes, M, undisclosed, DOUBT
Jack Stephens, D, undisclosed, OUT, estimated return Feb. 1
Ross Stewart, F, calf, OUT, estimated return Jan. 25