Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Aston Villa v Brighton & Hove Albion
Villa Park
Monday, 7.45 p.m. GMT / 2.45 p.m. ET
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Ian Maatsen | CB Tyrone Mings | CB Pau Torres | RB Ezri Konsa
DM Youri Tielemans | DM Boubacar Kamara
LW Morgan Rogers | AM John McGinn | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Matty Cash, D, suspension, due back Jan. 4
Jhon Durán, F, suspension, due back Jan. 15
Jacob Ramsey, M, hamstring, DOUBT
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Tariq Lamptey
DM Yasin Ayari | DM Carlos Baleba
LW Kaoru Mitoma | AM João Pedro | RW Yankuba Minteh
ST Georginio Rutter
Injury/suspension updates:
Jack Hinshelwood, M/D, knee, OUT, estimated return Jan. 4
Ferdi Kadioglu, M/D, toe, OUT, estimated return Jan. 4
James Milner, M/D, hamstring, OUT, estimated return Jan. 11
Adam Webster, D, hamstring, DOUBT
Danny Welbeck, F, ankle, OUT, estimated return Jan. 4
Mats Wieffer, M, undisclosed, DOUBT
Ipswich Town v Chelsea
Portman Road
Monday, 7.45 p.m. GMT / 2.45 p.m. ET
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Dara O'Shea | RB Ben Johnson
DM Jens Cajuste | DM Sam Morsy
LW Sammie Szmodics | AM Conor Chaplin | RW Omari Hutchinson
ST Liam Delap
Injury/suspension updates:
George Hirst, F, knee, OUT, estimated return Jan. 19
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Axel Tuanzebe, D, hamstring, OUT, estimated return Feb. 1
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Tosin Adarabioyo | CB Levi Colwill | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW João Félix | AM Cole Palmer | RW Pedro Neto
ST Christopher Nkunku
Injury/suspension updates:
Benoît Badiashile, D, undisclosed, OUT, estimated return Jan. 4
Kiernan Dewsbury-Hall, M, undisclosed, DOUBT
Wesley Fofana, D, hamstring, OUT, estimated return Jan. 4
Reece James, D, hamstring, OUT, estimated return Jan. 4
Romeo Lavia, M, undisclosed, DOUBT
Mykhailo Mudryk, F/M, not injury related, OUT, estimated return Jan. 25
Manchester United v Newcastle United
Old Trafford
Monday, 8 p.m. GMT / 3 p.m. ET
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Lisandro Martínez | CB Leny Yoro
LM Diogo Dalot | CM Christian Eriksen | CM Kobbie Mainoo | RM Noussair Mazraoui
AM Antony | AM Amad Diallo
ST Rasmus Højlund
Injury/suspension updates:
Bruno Fernandes, F/M, suspension, due back Jan. 5
Victor Lindelöf, D, concussion, DOUBT
Mason Mount, F/M, strain, OUT, estimated return Jan. 5
Luke Shaw, D, calf, OUT, estimated return Jan. 5
Manuel Ugarte, M, suspension, due back Jan. 5
Latest Newcastle United team news
Expected Lineup:
GK Martin Dúbravka
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Bruno Guimaraes | CM Sandro Tonali | CM Joe Willock
FWL Anthony Gordon | ST Alexander Isak | FWR Jacob Murphy
Injury/suspension updates:
Sven Botman, D, knee, DOUBT
Emil Krafth, D, collarbone, OUT, estimated return Jan. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Valentino Livramento, D, illness, DOUBT
Nick Pope, G, knee, OUT, estimated return Jan. 12
Kieran Trippier, D, leg, DOUBT
Callum Wilson, F, hamstring, OUT, estimated return Feb. 1
Brentford v Arsenal
Gtech Community Stadium
Wednesday, 5:30 p.m. GMT / 12:30 p.m. ET
Latest Brentford team news
Expected Lineup:
GK Hákon Valdimarsson
LB Keane Lewis-Potter | CB Nathan Collins | CB Kim Ji-Soo | RB Mads Roerslev
CM Mikkel Damsgaard | CM Vitaly Janelt | CM Christian Nørgaard
FWL Kevin Schade | ST Yoane Wissa | FWR Bryan Mbeumo
Injury/suspension updates:
Kristoffer Ajer, D, ankle, OUT, estimated return Feb. 2
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Mark Flekken, G, groin, DOUBT
Rico Henry, M/D, knee, OUT, estimated return Jan. 11
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Mathias Jensen, M, hamstring, DOUBT
Ben Mee, D, undisclosed, DOUBT
Igor Thiago, F, infection, OUT, estimated return Jan. 4
Gustavo Nunes, F/M, back, OUT, estimated return Jan. 11
Ethan Pinnock, D, hamstring, OUT, estimated return Jan. 18
Sepp van den Berg, D, groin, DOUBT
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhães | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Mikel Merino | CM Declan Rice
FWL Gabriel Martinelli | ST Kai Havertz | FWR Ethan Nwaneri
Injury/suspension updates:
Bukayo Saka, F/M, hamstring, OUT, estimated return Mar. 8
Raheem Sterling, F/M, knee, OUT, estimated return Jan. 15
Takehiro Tomiyasu, D, knee, OUT, estimated return Jan. 12
Ben White, D, knee, OUT, estimated return Jan. 15
Oleksandr Zinchenko, D, undisclosed, DOUBT