Peñarol had a 0-0 draw at home against Brazil´s Flamengo on Thursday to secure a spot in the Copa Libertadores semifinals for the first time in 13 years.
The Uruguayan club won the first leg 1-0 via a Javier Cabrera goal.
Peñarol will next play Botafogo, who beat Sao Paulo on penalties in an all-Brazil quarterfinal to reach the last four for the first time since 1973.
Five-time champion Peñarol have struggled in the last decade in the Copa Libertadores with group-stage exits in its previous nine appearances. The Uruguayans haven't reached this stage since a run to the final in 2011.
Peñarol were an underdog against Flamengo, which spent more than $50 million in the offseason attempting to build a team capable of earning the club a fourth Copa Libertadores title.
In the other semifinal, Argentina's River Plate will play against Brazil's Atletico Mineiro.
The Copa Libertadores final is scheduled for Nov. 30 in Buenos Aires. It's the home of River Plate, which advanced over Chile's Colo Colo. Atletico Mineiro defeated defending champion Fluminense 2-0 to reach the semifinals.
River Plate is led by coach Marcelo Gallardo, who returned after a brief stint with the Al-Ittihad in Saudi Arabia. Gallardo won Copa Libertadores titles with River Plate in 2015 and 2018.