Ederson will miss Manchester City's last Premier League game as well as the FA Cup final due to a broken right eye socket.
City said on Thursday that Ederson underwent scans after sustaining the injury during a collision with Cristian Romero in the 2-0 win over Tottenham on Tuesday.
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The Brazil international played on briefly but eventually was substituted, and his replacement, Stefan Ortega, pulled off key saves from Dejan Kulusevski and Son Heung-Min.
"The injury will prevent Ederson from playing any further part in the remaining games of the 2023-24 season," City said in their statement.
City plays West Ham at home on Sunday and need a win to guarantee a record fourth straight top-flight title. Pep Guardiola's side then take on Manchester United in the FA Cup final on May 25.
Ederson was selected last week in Brazil's squad for the Copa América in the United States in June and July.