Big wins over France and Scotland have put England in a strong position heading into the final two weeks of the tournament.
Meanwhile, Italy are coming off a heavy defeat to France in Round 3 and will hope for much better showing at Twickenham.
Here is everything you need to know about Sunday's clash.
Key details:
When: Sunday, March 9 at 3 p.m. UK
Where: Allianz Stadium, Twickenham
How to watch: You can wach live on the ITV (UK). You can also follow along with live updates on ESPN.
Officials: Referee: Andrew Brace (Ire)
Assistant Referees: Craig Evans (Wal) & Luc Ramos (Fra)
Television Match Official: Marius Jonker (SA)
Lineups:
England: To be announced.
Replacements:
Italy: To be announced.
Replacements:
Team news:
England:
Italy:
Information from Reuters contributed to the team news of this report.