Both Scotland and Wales have so far had tournaments they would prefer to forget.
Scotland have been undone by injuries and a narrow 16-15 loss to England, while Wales remain winless although they showed signs of life after Warren Gatland left his role as head coach part way through the tournament.
Both sides will be desperate to end on a high in the final two games.
Here is everything you need to know about Saturday's clash.
Key details:
When: Saturday, March 8 at 4.45 p.m. UK
Where: Murrayfield, Edinburgh
How to watch: You can watch live on the BBC (UK). You can also follow along with live updates on ESPN.
Officials: Referee: Andrea Piardi (Ita)
Assistant Referees: Nic Berry (Aus) & Gianluca Gnecchi (Ita)
Television Match Official: Eric Gauzins (Fra)
Lineups:
Scotland: Pierre Schoeman, Dave Cherry, Zander Fagerson, Jonny Gray, Grant Gilchrist, Jamie Ritchie, Rory Darge (co-captain), Jack Dempsey, Ben White, Finn Russell (co-captain), Duhan van der Merwe, Tom Jordan, Huw Jones, Darcy Graham, Blair Kinghorn.
Replacements: Ewan Ashman, Rory Sutherland, Will Hurd, Gregor Brown, Matt Fagerson, George Horne, Stafford McDowall, Kyle Rowe.
Wales: Nicky Smith, Elliot Dee, WillGriff John, Dafydd Jenkins, Will Rowlands, Jac Morgan (captain), Tommy Reffell, Taulupe Faletau, Tomos Williams, Gareth Anscombe, Ellis Mee, Ben Thomas, Max Llewellyn, Tom Rogers, Blair Murray.
Replacements: Dewi Lake, Gareth Thomas, Keiron Assiratti, Teddy Williams, Aaron Wainwright, Rhodri Williams, Jarrod Evans, Joe Roberts.
Team news:
Scotland: Winger Darcy Graham will return for Scotland in the only change to the team narrowly beaten by England in their last game.
Graham suffered concussion after colliding with teammate Finn Russell in the first half of the home defeat by Ireland last month and did not recover in time for the 16-15 loss at Twickenham on Feb. 22.
Wales: Wales have named an unchanged starting XV for the first time since the 2019 Rugby World Cup as interim coach Matt Sherratt keeps faith with the selection that lost to Ireland.
Crucially, fly-half Gareth Anscombe has been cleared to play, recovering from a suspected concussion after leaving the field against Ireland, to play alongside scrum-half Tomos Williams.
Information from Reuters contributed to the team news of this report.
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