Brisbane have kept their top-four hopes alive with a 60-14 whipping of South Sydney, but suffered a huge blow with prop Xavier Willison suffering a suspected broken arm.
Recalled winger Selwyn Cobbo was brilliant and fullback Reece Walsh had four try assists and a try in a powerful riposte to his poor display against Parramatta the previous week.
The error-ridden Rabbitohs remain in last place and their ninth loss in a row is now Wayne Bennett's worst losing streak in his 38 years as coach in the premiership.
The loss of Willison in the 48th minute, likely for the season, is a concern in the run to the finals with fellow prop Ben Te Kura (broken foot) also out of action.
Broncos coach Michael Maguire said before the match that he wanted Walsh to pick his moments and chime in at the right time rather than overplaying his hand.
Walsh took the advice on board to set up two tries in the first half as Brisbane took an 18-8 lead into the break.
Cobbo had several nice touches and raced 53m to score straight after halftime. Fellow winger Deine Mariner, also brought back into the side, was at his dazzling best with a double.
Ezra Mam and Kotoni Staggs both scored twice as the Broncos romped home.
Brisbane, on 28 points, are now just two points behind the fourth-placed Warriors and travel to Melbourne on Thursday night.
The hosts lost forwards Payne Haas (skin infection) and Brendan Piakura (concussion) in the 24 hours before kick-off but had too much class for the hapless Rabbitohs.
Broncos captain Adam Reynolds became the second player in premiership history to score 2500 points and now is only behind Cameron Smith (2786 points).
Walsh and Mam interchanged passes in a slick long-range try for the latter to open the scoring.
Reynolds then conjured a trademark try for Jack Gosiewski with a deft grubber.
Rabbitohs five-eighth Lewis Dodd set up a try with a neat cross-field bomb for winger Bayleigh Bentley-Hape to score.
Walsh found the perfect pass for Kotoni Staggs to surge over but Souths spun it as the halftime siren sounded for centre Tallis Duncan to score.
The hosts ran away with it in the second half in a total demolition.