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Tennessee Titans schedule 2025 -- takeaways, predictions

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Titans take medical commercial route for schedule release (1:03)

The Tennessee Titans parody a medical commerical to showcase their 2025 NFL schedule. (1:03)

NASHVILLE, Tenn. -- The Tennessee Titans' 2025 schedule was released along with the rest of the NFL slate Wednesday.

Titans coach Brian Callahan and rookie quarterback Cam Ward will get an early test when they travel to Denver to face the Broncos in the season opener. Denver's defense was among the best in the league last season.

Titans defensive coordinator Dennard Wilson's pass defense will square up against some of the league's top passers in Matthew Stafford, Patrick Mahomes, C.J. Stroud, Justin Herbert and Brock Purdy. The defense will get pushed to the limit in the home opener when they face Stafford and the Los Angeles Rams' high-scoring offense in Week 2.

Here's what's in store for the Titans:

Titans 2025 regular-season schedule

Week 1: Sept. 7 at Denver Broncos

Week 2: Sept. 14 vs. Los Angeles Rams

Week 3: Sept. 21 vs. Indianapolis Colts

Week 4: Sept. 28 at Houston Texans

Week 5: Oct. 05 at Arizona Cardinals

Week 6: Oct. 12 at Las Vegas Raiders

Week 7: Oct. 19vs. New England Patriots

Week 8: Oct. 26 at Colts

Week 9: Nov. 2 vs. Los Angeles Chargers

Week 10: BYE

Week 11: Nov. 16 vs. Texans

Week 12: Nov. 23 vs. Seattle Seahawks

Week 13: Nov. 30 vs. Jacksonville Jaguars

Week 14: Dec. 7 at Cleveland Browns

Week 15: TBD at San Francisco 49ers

Week 16: Dec. 21 vs. Kansas City Chiefs

Week 17: Dec. 28 vs. New Orleans Saints

Week 18: TBD at Jaguars

*Date for Weeks 15 and 18 are to be determined

Strength of schedule: The Titans have the fourth-easiest schedule in the league (opponents had a .450 winning percentage in 2024).

Over/Under: 5.5 wins

Biggest takeaway

This season's schedule is another year of minimal prime-time games, but worse -- as the Titans don't have any games under the lights. This comes after Tennessee had one prime-time matchup last season, one fewer than 2023 when they faced the Steelers on "Thursday Night Football" in Week 9 and the Dolphins on "Monday Night Football" in Week 14. If Ward can work some magic on the field, the Titans could gain a prime-time game later in the season by being flexed to a "Sunday Night Football" game or to a Saturday game.

Circle this date

Former Titans coach Mike Vrabel returns to Nissan Stadium with the Patriots in Week 7 for what will be one of Tennessee's most anticipated games of the year. Titans controlling owner Amy Adams-Strunk would like nothing more than to beat Vrabel, who she fired after serving as coach from 2018 to 2023 in Tennessee. Callahan's future beyond 2025 would get a boost with a win over New England. The matchup will also feature the return to Nashville for outside linebacker Harold Landry III among other former Titans players and coaches.

Key stretch

Weeks 3-8 will be a critical stretch for the Titans because they'll have three games against AFC South opponents in those five weeks. They start by hosting the Colts at Nissan Stadium on Sept. 21 and face the Texans at Houston the following week. Two cross-country trips to Arizona and Las Vegas precede what will be an emotional game against Vrabel's Patriots in Nashville. Tennessee finishes the stretch when it travels to Indianapolis on Oct. 26.

Bold prediction

The Titans will win both of their back-to-back trips to the West Coast in October. The first win will come in a clash of No.1 picks when Ward leads the Titans over Kyler Murray's Cardinals. The second one will be over the Raiders in Las Vegas. That will put the Titans at 3-3 heading into their match up with New England in Week 7.

What will Cam Ward's breakout game be?

Ward's best opportunity for a breakout game will be in Week 8 against the Colts. Indianapolis will be the first defense that Ward sees twice, and it comes a little over a month after facing the Colts for the first time on Sept. 21. The Colts' secondary was 26th in the league last year in passing yards allowed (229.4), but they added veteran cornerback Charvarius Ward. Things should start to slow down for Cam Ward halfway into the season while facing a familiar opponent.