Anthony Davis did not play in the Lakers' 105-102 loss to the Indiana Pacers on Tuesday due to a mild ankle sprain.
It was the second game Davis has missed this season. He is leading the team in points (27.4), rebounds (9.3) and blocks (2.6) per game.
In Davis' absence, Jared Dudley made his first start of the season for the Lakers (24-4), who are tied with the Milwaukee Bucks for the NBA's best record.
Davis tweaked the ankle during Sunday's win against the Atlanta Hawks. He grabbed at his right ankle when fouled on a layup in the closing minutes, but he was able to finish the game.
He was listed as questionable on the injury report leading into Tuesday's game.
Davis has dealt with rib and shoulder soreness this season.
Kyle Kuzma (ankle) was also out for Los Angeles, as previously announced.