| Jul 19, 2025 | Max Holloway | L | Decision - Unanimous | 5 | 5:00 | UFC 318: Holloway vs. Poirier 3 |
| Jun 1, 2024 | Islam Makhachev | L | Submission | 5 | 2:42 | UFC 302: Makhachev vs. Poirier |
| Mar 9, 2024 | Benoît Saint Denis | W | KO/TKO | 2 | 2:32 | UFC 299: O'Malley vs. Vera 2 |
| Jul 29, 2023 | Justin Gaethje | L | KO/TKO | 2 | 1:00 | UFC 291: Poirier vs. Gaethje 2 |
| Nov 12, 2022 | Michael Chandler | W | Submission | 3 | 2:00 | UFC 281: Adesanya vs. Pereira |
| Dec 11, 2021 | Charles Oliveira | L | Submission | 3 | 1:02 | UFC 269: Oliveira vs. Poirier |
| Jul 10, 2021 | Conor McGregor | W | TKO - Doctor's Stoppage | 1 | 5:00 | UFC 264: Poirier vs. McGregor 3 |
| Jan 23, 2021 | Conor McGregor | W | KO/TKO | 2 | 2:32 | UFC 257: Poirier vs. McGregor 2 |
| Jun 27, 2020 | Dan Hooker | W | Decision - Unanimous | 5 | 5:00 | UFC Fight Night: Poirier vs. Hooker |
| Sep 7, 2019 | Khabib Nurmagomedov | L | Submission | 3 | 2:06 | UFC 242: Khabib vs. Poirier |
| Apr 13, 2019 | Max Holloway | W | Decision - Unanimous | 5 | 5:00 | UFC 236: Holloway vs. Poirier 2 |
| Jul 28, 2018 | Eddie Alvarez | W | KO/TKO | 2 | 4:05 | UFC Fight Night: Alvarez vs. Poirier 2 |
| Apr 14, 2018 | Justin Gaethje | W | KO/TKO | 4 | 0:33 | UFC Fight Night: Poirier vs. Gaethje |
| Nov 11, 2017 | Anthony Pettis | W | KO/TKO | 3 | 2:08 | UFC Fight Night: Poirier vs. Pettis |
| May 13, 2017 | Eddie Alvarez | D | No Contest | 2 | 4:02 | UFC 211: Miocic vs. dos Santos 2 |
| Feb 11, 2017 | Jim Miller | W | Decision - Majority | 3 | 5:00 | UFC 208: Holm vs. de Randamie |
| Sep 17, 2016 | Michael Johnson | L | KO/TKO | 1 | 1:35 | UFC Fight Night: Poirier vs. Johnson |
| Jun 4, 2016 | King Green | W | KO/TKO | 1 | 2:53 | UFC 199: Rockhold vs. Bisping 2 |
| Jan 2, 2016 | Joe Duffy | W | Decision - Unanimous | 3 | 5:00 | UFC 195: Lawler vs. Condit |
| Jun 6, 2015 | Yancy Medeiros | W | KO/TKO | 1 | 2:38 | UFC Fight Night: Boetsch vs. Henderson |
| Apr 4, 2015 | Diego Ferreira | W | KO/TKO | 1 | 3:45 | UFC Fight Night: Mendes vs. Lamas |
| Sep 27, 2014 | Conor McGregor | L | KO/TKO | 1 | 1:46 | UFC 178: Johnson vs. Cariaso |
| Apr 16, 2014 | Akira Corassani | W | KO/TKO | 2 | 0:42 | UFC Fight Night: Bisping vs. Kennedy |
| Dec 28, 2013 | Diego Brandao | W | KO/TKO | 1 | 4:54 | UFC 168: Weidman vs. Silva 2 |
| Aug 31, 2013 | Erik Koch | W | Decision - Unanimous | 3 | 5:00 | UFC 164: Henderson vs. Pettis 2 |
| Feb 16, 2013 | Cub Swanson | L | Decision - Unanimous | 3 | 5:00 | UFC on FUEL TV: Barao vs. McDonald |
| Dec 15, 2012 | Jonathan Brookins | W | Submission | 1 | 4:15 | The Ultimate Fighter 16 Finale |
| May 15, 2012 | Chan Sung Jung | L | Submission | 4 | 1:07 | UFC on Fuel TV: Korean Zombie vs. Poirier |
| Feb 4, 2012 | Max Holloway | W | Submission | 1 | 3:23 | UFC 143: Diaz vs. Condit |
| Nov 12, 2011 | Pablo Garza | W | Submission | 2 | 1:32 | UFC on Fox: Velasquez vs. dos Santos |
| Jun 11, 2011 | Jason Young | W | Decision - Unanimous | 3 | 5:00 | UFC 131: Dos Santos vs. Carwin |
| Jan 1, 2011 | Josh Grispi | W | Decision - Unanimous | 3 | 5:00 | UFC 125: Resolution |
| Nov 11, 2010 | Zachary Micklewright | W | KO/TKO | 1 | 0:53 | WEC 52: Faber vs. Mizugaki |
| Aug 18, 2010 | Danny Castillo | L | Decision - Unanimous | 3 | 5:00 | WEC 50: Cruz vs. Benavidez 2 |
| Jun 18, 2010 | Derek Gauthier | W | KO | 1 | 0:57 | Ringside MMA 7: No Escape |
| Mar 6, 2010 | Derrick Krantz | W | Submission (Armbar) | 2 | 3:35 | USA MMA: Night of Champions 2 |
| Nov 13, 2009 | Ronnie Lis | W | Submission (Armbar) | 1 | 0:51 | USA MMA: Border War 2 |
| Aug 16, 2008 | Daniel Watts | W | KO | 1 | 1:26 | BFC: Bang Fighting Championships |
| Aug 1, 2009 | Joe Torrez | W | TKO | 1 | 2:37 | USA MMA 8: Natural Disaster 3 |
| Jun 26, 2009 | Nate Jolly | W | Submission (Armbar) | 2 | 3:54 | CFC: Cajun Fighting Championships |
| May 16, 2009 | Aaron Suarez | W | KO | 1 | 1:19 | USA MMA 7: River City Rampage |
