Zach Edey and No. 24 Purdue shook off a slow start. When No. 8 Duke tried to rally in the second half, the Boilermakers finished strong.
Edey had 21 points and 12 rebounds, and Purdue beat Duke 75-56 on Sunday in the championship game of the Phil Knight Legacy men's tournament.
Fletcher Loyer scored 18 points for Purdue (6-0), and reserve Caleb Furst finished with 11 points and 10 rebounds.
"I feel like we weren't getting the looks we wanted early. As we settled into the game, we kept our poise and kept getting the shots that we wanted," Edey said. "They were making some tough 2s at the beginning of the game, shots we're OK with all season."
The 7-foot-4 Edey was 7-for-13 from the field and 7-for-8 at the line. He was named tournament MVP.
"They have the most unique player in the country," Duke coach Jon Scheyer said of Edey. "He's a hard guy to prepare for because there's nobody else like him."
Duke (6-2) shot 36.2% (21-for-58) from the field. Tyrese Proctor scored 16 points for the Blue Devils. Kyle Filipowski and Jeremy Roach each had 14.
Ethan Morton had a steal and a dunk to help Purdue open a 58-41 lead with 15:37 left in the second half.
Duke countered with an 8-0 run, capped by two foul shots by Dariq Whitehead. But Furst made a layup and a jumper to help hold off the Blue Devils.
A hook shot by Edey and a 3-pointer by Loyer made it 68-56 with 5:03 remaining.
Duke got off to a 14-7 start before Purdue worked its way back into the game.
"I don't feel like we came out bad today, but they matched our energy," Edey said.
A 3-pointer by Brandon Newman pushed the Purdue lead to 46-28. A late run by Duke cut the Boilermakers' lead to 46-35 at halftime.
The Associated Press contributed to this story.