Fantasy baseball lineup advice and betting tips for Tuesday

ESPN Fantasy

Sep 22, 2025, 05:13 PM ET

Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. MLB betting tips for each day's slate of games will also be added in the morning. MLB game odds are provided by ESPN BET, and all fantasy advice is geared toward ESPN 10-team leagues with standard scoring.

Note: All information is accurate as of the time of publication. For updates, including what you might have missed from last night, as well as any breaking news that might impact today's MLB slate, be sure to check out the latest fantasy baseball news.

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STARTING PITCHERS FOR TUESDAY

Pitchers are ranked in order of their Forecaster/Daily Notes projected fantasy points (FPTS), using ESPN's standard scoring system (2 points per win, minus-2 per loss, 3 per inning, 1 per K, minus-1 apiece per hit or walk allowed, minus-2 per earned run allowed).

T: The pitcher's handedness. OPP: Opposing team. RST%: The pitcher's roster percentage in ESPN leagues. ML: ESPN BET Money Line. O/U: ESPN BET Over/Under for runs scored. For the projected stat line, W% is the team's win probability using ESPN projections, IP is innings pitched, ER is earned runs allowed and K is strikeouts.

If a team is planning on using an "opener" to start their game, but will rely on a "bulk pitcher" to follow him on the mound after 1-2 innings, the bulk pitcher is listed and indicated with an asterisk.

FPTS	Pitcher	T	Opp	Rst%	W%	IP	ER	K
15.1	Tarik Skubal	L	@CLE	99.8%	61%	6.0	1.9	6.8
12.9	Cristopher Sanchez	L	MIA	95.9%	64%	6.2	2.4	5.9
12.5	Bryce Miller	R	COL	52.3%	69%	5.6	2.1	5.7
11.3	Kevin Gausman	R	BOS	91.5%	54%	5.9	2.6	5.7
11.0	Logan Webb	R	STL	97.8%	53%	6.1	2.6	5.5
10.8	Luis Gil	R	CWS	32.1%	54%	5.4	2.1	5.5
10.7	Brady Singer	R	PIT	49.6%	53%	5.6	2.5	5.7
10.5	Jacob deGrom	R	MIN	96.5%	65%	5.3	2.5	5.6
10.1	David Peterson	L	@CHC	38.6%	59%	5.8	2.6	5.3
9.4	Cole Ragans	L	@LAA	71.6%	60%	5.2	2.7	6.4
9.3	Cade Horton	R	NYM	47.7%	41%	5.1	2.1	4.6
9.3	Ryan Pepiot	R	@BAL	47.2%	53%	5.1	2.4	5.3
9.3	Shane Smith	R	@NYY	9.1%	46%	5.1	2.3	5.3
9.0	Edward Cabrera	R	@PHI	20.8%	36%	5.2	2.5	5.6
8.4	Dean Kremer	R	TB	7.2%	47%	5.5	2.9	4.8
8.0	Gavin Williams	R	DET	40.2%	39%	5.1	2.6	5.5
7.9	Cristian Javier	R	@ATH	5.7%	51%	4.9	2.4	4.6
7.7	Randy Vasquez	R	MIL	1.9%	69%	5.0	2.3	3.5
7.6	Brandon Pfaadt	R	LAD	55.9%	48%	5.4	3.1	5.1
7.6	Lucas Giolito	R	@TOR	31.1%	46%	5.5	2.8	4.7
7.5	Andre Pallante	R	@SF	3.1%	47%	5.4	2.6	4.2
7.3	Johan Oviedo	R	@CIN	1.5%	47%	4.6	2.5	5.0
7.1	Jeffrey Springs	L	HOU	13.8%	49%	5.2	2.9	4.6
5.8	McCade Brown	R	@SEA	0.2%	31%	4.3	2.3	4.3
5.5	Zebby Matthews	R	@TEX	2.8%	35%	4.9	3.2	4.9
5.4	Shohei Ohtani	R	@ARI	99.9%	52%	3.2	1.5	3.4
5.2	Hurston Waldrep	R	WSH	37.6%	52%	4.9	3.3	5.1
4.9	Sam Aldegheri	L	KC	0.0%	40%	4.8	3.1	4.2
4.5	Brad Lord	R	@ATL	1.1%	48%	4.5	3.1	4.1
	TBD		@SD	0.0%	31%	0.0	0.0	0.0

Pitchers to stream Tuesday

A solid rule of thumb down the stretch is to trust players with something on the line. Luis Gil wasn't his usual solid self in his last outing, but the New York Yankees are in the throes of a playoff push, and Gil was effective leading up to last week's hiccup. He was 4-0 with a 1.89 ERA and 1.29 WHIP over his seven previous starts, albeit with just 31 strikeouts in 38 innings, and he walked a generous 23 batters. Even so, Gil merits streaming consideration facing the Chicago White Sox, who sport the second-worst wOBA against right-handers.
Hunter Greene is the unabashed ace of the Cincinnati Reds, but the club would not be in the NL wild-card picture without the second-half exploits of Brady Singer. After a disaster in his first start after the break, Singer was 7-2 with a 2.15 ERA and 0.94 WHIP, supported by 62 punchouts to only 17 free passes in 58 2/3 innings. The righty enjoys a favorable home matchup against the Pittsburgh Pirates, the league's least potent offense against a righty on the hill.
The Chicago Cubs secured a wild-card spot, but they would like to lock down the top spot, earning home-field advantage in the short three-game wild-card round. Cade Horton is also putting the finishing touches on a possible NL Rookie of the Year season when he toes the Wrigley Field rubber against the New York Mets. The Mets are fighting for their playoff lives, but Horton is still in a good position facing a club with a 7-12 record this month.

Hitters to stream Tuesday

Batters in meaningful games also warrant an extra level of trust. The Seattle Mariners are in the driver's seat in the AL West as they begin a home set with the Colorado Rockies. They face McCade Brown and his 9.17 ERA and 2.09 WHIP. Jorge Polanco, Victor Robles and J.P. Crawford are the main hitting beneficiaries in the matchup.

Betting tips

Best/worst pitcher/hitter matchups and betting projections are generated by THE BAT X, a system created by Derek Carty using advanced methods like those used in MLB front offices, accounting for a variety of factors including player talent, ballparks, bullpens, weather, umpires, defense, catcher pitch-framing, and lots more. Betting projections for every player, team, and game can be found at EV Analytics.

Note: Expected Value is a measure of how good a bet is, factoring the probability that it will win versus the odds the book is providing. If you were to wager $1.00 100 times on a bet with an Expected Value of $25, you would win some and you would lose some, but in the end you would expect to come away with $25 in profit on your $100 investment.

Because odds typically do not get set until the previous day's games are completed, betting tips will be added in the morning.