Notre Dame and Pittsburgh will start Saturday's action at noon ET, in a showdown of ranked opponents. Notre Dame hasn't lost since losing its first two games, and has climbed back into the top 10 of the College Football Playoff rankings. Meanwhile, Pitt has been the No. 11 passing offense since turning to Mason Heintschel at QB. The Panthers have won five games in a row to put themselves back in the ACC race. "College GameDay" will be in Pittsburgh Saturday morning to get the college football day started.
Afterward, three other matchups feature ranked opponents. In the Big Ten, Iowa travels to face USC, while the SEC will feature Oklahoma-Alabama and Texas-Georgia. The latter matchup is a rematch of last season's SEC Championship game.
Current rankings below are from last week's College Football Playoff rankings, and will be updated after Tuesday's reveal.
All times Eastern. For latest lines, go to ESPN BET
Clemson at No. 15 Louisville -3.5
Friday, 7:30 p.m., ESPN
Records: Clemson 4-5, 0-1 vs. AP teams; Louisville 7-2, 1-1 vs. AP teams
Opening Line: Louisville -3.5, O/U 51.5
Money line: Clemson (+135); Louisville (-155)
Over/Under: 50.5 (O -105, U -115)
FPI Projection Louisville by 1.2 points with a 55% probability to win game outright
Minnesota at No. 9 Oregon -24.5
Friday, 9 p.m., FOX
Records: Minnesota 6-3, 1-1 vs. AP teams; Oregon 8-1, 1-1 vs. AP teams
Line Movement Alert: Opened Oregon -21.5, O/U 44.5
Money line: Off
Over/Under: 43.5 (O -115, U -105)
FPI Projection Oregon by 25.4 points with a 96% probability to win game outright
Wisconsin at No. 2 Indiana -30.5
Saturday, Noon, BTN
Records: Wisconsin 3-6, 1-4 vs. AP teams; Indiana 10-0, 2-0 vs. AP teams
Opening Line: Indiana -30.5, O/U 43.5
Money line: Off
Over/Under: 44.5 (O -110, U -110)
FPI Projection Indiana by 28.7 points with a 97% probability to win game outright
South Carolina at No. 3 Texas A&M -18.5
Saturday, Noon, ESPN
Records: South Carolina 3-6, 0-5 vs. AP teams; Texas A&M 9-0, 3-0 vs. AP teams
Opening Line: Texas A&M -17.5, O/U 48.5
Money line: South Carolina (+1000); Texas A&M (-2000)
Over/Under: 47.5 (O -115, U -105)
FPI Projection Texas A&M by 12.5 points with an 85% probability to win game outright
No. 10 Notre Dame -10.5 at No. 24 Pittsburgh
Saturday, Noon, ABC
Records: Notre Dame 7-2, 1-2 vs. AP teams; Pittsburgh 7-2, 1-0 vs. AP teams
Opening Line: Notre Dame -11.5, O/U 56.5
Money line: Notre Dame (-425); Pittsburgh (+320)
Over/Under: 55.5 (O -105, U -115)
FPI Projection Notre Dame by 8.1 points with a 77% probability to win game outright
No. 21 Michigan -11.5 at Northwestern
Saturday, Noon, FOX
Records: Michigan 7-2, 0-1 vs. AP teams; Northwestern 5-4, 0-2 vs. AP teams
Opening Line: Michigan -10.5, O/U 40.5
Money line: Michigan (-550); Northwestern (+380)
Over/Under: 41.5 (O -105, U -115)
FPI Projection Michigan by 9 points with a 79% probability to win game outright
No. 12 Oklahoma at No. 4 Alabama -6.5
Saturday, 3:30 p.m., ABC
Records: Oklahoma 7-2, 3-1 vs. AP teams; Alabama 8-1, 4-0 vs. AP teams
Opening Line: Alabama -7.5, O/U 45.5
Money line: Oklahoma (+180); Alabama (-215)
Over/Under: 46.5 (O -105, U -115)
FPI Projection Alabama by 5.8 points with a 72% probability to win game outright
UCF at No. 8 Texas Tech -23.5
Saturday, 3:30 p.m., FOX
Records: UCF 4-5, 0-0 vs. AP teams; Texas Tech 9-1, 2-0 vs. AP teams
Opening Line: Texas Tech -23.5, O/U 47.5
Money line: UCF (+1300); Texas Tech (-4000)
Over/Under: 47.5 (O -115, U -105)
FPI Projection Texas Tech by 18.2 points with a 91% probability to win game outright
No. 14 Virginia at Duke -6.5
Saturday, 3:30 p.m., ESPN2
Records: Virginia 8-2, 1-0 vs. AP teams; Duke 5-4, 0-2 vs. AP teams
Opening Line: Duke -6.5, O/U 59.5
Money line: Virginia (+190); Duke (-225)
Over/Under: 57.5 (O -120, U EVEN)
FPI Projection Duke by 2.5 points with a 61% probability to win game outright
No. 17 Georgia Tech -16.5 at Boston College
Saturday, 3:30 p.m., ACC Network
Records: Georgia Tech 8-1, 1-0 vs. AP teams; Boston College 1-9, 0-2 vs. AP teams
Opening Line: Georgia Tech -16.5, O/U 57.5
Money line: Georgia Tech (-1000); Boston College (+550)
Over/Under: 58.5 (O -110, U -110)
FPI Projection Georgia Tech by 14.3 points with a 87% probability to win game outright
NC State at No. 18 Miami -15.5
Saturday, 3:30 p.m., ESPN
Records: NC State 5-4, 1-1 vs. AP teams; Miami 7-2, 3-0 vs. AP teams
Opening Line: Miami -14.5, O/U 55.5
Money line: NC State (+550); Miami (-900)
Over/Under: 55.5 (O -110, U -110)
FPI Projection Miami by 15 points with a 88% probability to win game outright
No. 20 Iowa at No. 19 USC -6.5
Saturday, 3:30 p.m.,
Records: Iowa 6-3, 0-3 vs. AP teams; USC 7-2, 1-2 vs. AP teams
Opening Line: USC -6.5, O/U 49.5
Money line: Iowa (+210); USC (-250)
Over/Under: 49.5 (O -115, U -105)
FPI Projection USC by 7.5 points with a 76% probability to win game outright
New Mexico State at No. 25 Tennessee -39.5
Saturday, 4:15 p.m., SEC Network
Records: New Mexico State 4-5, 0-1 vs. AP teams; Tennessee 6-3, 0-3 vs. AP teams
Opening Line: Tennessee -38.5, O/U 61.5
Money line: Off
Over/Under: 61.5 (O -115, U -105)
FPI Projection Tennessee by 38.8 points with a >99% probability to win game outright
Florida at No. 6 Ole Miss -16.5
Saturday, 7 p.m., ESPN
Records: Florida 3-6, 1-4 vs. AP teams; Ole Miss 9-1, 2-1 vs. AP teams
Line Movement Alert: Opened Ole Miss -13.5, O/U 52.5
Money line: Florida (+550); Ole Miss (-900)
Over/Under: 53.5 (O -115, U -105)
FPI Projection Ole Miss by 10 points with an 81% probability to win game outright
No. 13 Utah -10.5 at Baylor
Saturday, 7 p.m., ESPN2
Records: Utah 7-2, 2-2 vs. AP teams; Baylor 5-4, 1-1 vs. AP teams
Line Movement Alert: Opened Utah -7.5, O/U 60.5
Money line: Utah (-360); Baylor (+280)
Over/Under: 60.5 (O -105, U -115)
FPI Projection Utah by 8.7 points with a 79% probability to win game outright
Purdue at No. 23 Washington -16.5
Saturday, 7 p.m., FS1
Records: Purdue 2-8, 0-4 vs. AP teams; Washington 6-3, 1-1 vs. AP teams
Opening Line: Washington -15.5, O/U 52.5
Money line: Purdue (+600); Washington (-1000)
Over/Under: 53.5 (O -110, U -110)
FPI Projection Washington by 15.3 points with an 89% probability to win game outright
UCLA at No. 1 Ohio State -31.5
Saturday, 7:30 p.m., NBC
Records: UCLA 3-6, 1-1 vs. AP teams; Ohio State 9-0, 2-0 vs. AP teams
Opening Line: Ohio State -30.5, O/U 48.5
Money line: UCLA (+3500); Ohio State (-50000)
Over/Under: 48.5 (O -110, U -110)
FPI Projection Ohio State by 33.9 points with a 98% probability to win game outright
No. 11 Texas at No. 5 Georgia -6.5
Saturday, 7:30 p.m., ABC
Records: Texas 7-2, 2-1 vs. AP teams; Georgia 8-1, 2-1 vs. AP teams
Opening Line: Georgia -6.5, O/U 49.5
Money line: Texas (+180); Georgia (-215)
Over/Under: 48.5 (O -110, U -110)
FPI Projection Georgia by 2.3 points with a 60% probability to win game outright
Mississippi State at No. 22 Missouri -6.5
Saturday, 7:45 p.m., SEC Network
Records: Mississippi State 5-5, 1-4 vs. AP teams; Missouri 6-3, 0-3 vs. AP teams
Opening Line: Missouri -5.5, O/U 51.5
Money line: Mississippi State (+195); Missouri (-230)
Over/Under: 51.5 (O -115, U -105)
FPI Projection Missouri by 7.1 points with a 75% probability to win game outright
TCU at No. 7 BYU -6.5
Saturday, 10:15 p.m., ESPN
Records: TCU 6-3, 0-0 vs. AP teams; BYU 8-1, 1-1 vs. AP teams
Opening Line: BYU -4.5, O/U 51.5
Money line: TCU (+170); BYU (-200)
Over/Under: 52.5 (O -110, U -110)
FPI Projection BYU by 6.7 points with a 74% probability to win game outright