When No. 8 BYU takes on No. Texas Tech, it will be the first Big 12 matchup between top-10 teams since 2021. For Texas Tech, it is the first time they've been favored over a top-10 opponent since 2008, back when Graham Harrell and Michael Crabtree were walking the sidelines. ESPN College Gameday will be in Lubbock, Texas to start off the day of college football.
The only other matchup between two ranked teams comes in the SEC, as No. 3 Texas A&M travel north to face No. 19 Missouri.
Notre Dame are the highest-ranked two-loss team, as they rise up to No. 10 and will host Navy at 7:30 p.m. in South Bend.
Out in the Big Ten, No. 2 Indiana will be favored for the first time in program history against Penn State. This will be the 28th meeting between the two schools, and the last time they faced off in 2023, the Nittany Lions were 30.5-point favorites according to ESPN Research.
At night on ABC, No. 4 Alabama will welcome LSU to Tuscaloosa. Alabama opens as 10.5-point favorites over the struggling Tigers, and are 8-2 ATS as home favorites under head coach Kalen DeBoer.
All times Eastern. For latest lines, go to ESPN BET
Northwestern at No. 20 USC -14.5
Friday, 9 p.m., FOX
Records: Northwestern 5-3, 0-1 vs. AP teams; USC 6-2, 1-2 vs. AP teams
Opening Line: USC -15.5, O/U 51.5
Money line: Off
Over/Under: 52.5 (O -105, U -115)
FPI Projection USC by 17.5 points with a 91% probability to win game outright
Tulane at No. 22 Memphis -6.5
Friday, 9 p.m., ESPN
Records: Tulane 6-2, 0-1 vs. AP teams; Memphis 8-1, 1-0 vs. AP teams
Opening Line: Memphis -7.5, O/U 57.5
Money line: Off
Over/Under: 55.5 (O -110, U -110)
FPI Projection Memphis by 6.2 points with a 72% probability to win game outright
No. 2 Indiana -16.5 at Penn State
Saturday, Noon,
Records: Indiana 9-0, 2-0 vs. AP teams; Penn State 3-5, 0-2 vs. AP teams
Line Movement Alert: Opened Indiana -13.5, O/U 48.5
Money line: Off
Over/Under: 49.5 (O -110, U -110)
FPI Projection Indiana by 10.9 points with a 83% probability to win game outright
No. 5 Georgia -7.5 at Mississippi State
Saturday, Noon, ESPN
Records: Georgia 7-1, 2-1 vs. AP teams; Mississippi State 5-4, 1-3 vs. AP teams
Opening Line: Georgia -8.5, O/U 57.5
Money line: Off
Over/Under: 57.5 (O -105, U -115)
FPI Projection Georgia by 8.7 points with a 79% probability to win game outright
No. 8 BYU at No. 9 Texas Tech -10.5
Saturday, Noon, ABC
Records: BYU 8-0, 1-0 vs. AP teams; Texas Tech 8-1, 1-0 vs. AP teams
Opening Line: Texas Tech -10.5, O/U 52.5
Money line: Off
Over/Under: 53.5 (O -110, U -110)
FPI Projection Texas Tech by 2.7 points with a 61% probability to win game outright
No. 1 Ohio State -29.5 at Purdue
Saturday, 1 p.m., BTN
Records: Ohio State 8-0, 2-0 vs. AP teams; Purdue 2-7, 0-3 vs. AP teams
Line Movement Alert: Opened Ohio State -26.5, O/U 47.5
Money line: Off
Over/Under: 48.5 (O EVEN, U -120)
FPI Projection Ohio State by 29.1 points with a 97% probability to win game outright
The Citadel at No. 7 Ole Miss
Saturday, 1 p.m., SECN+
Records: The Citadel 4-5 (4th in Southern); Ole Miss 8-1, 2-1 vs. AP teams
No line posted
FPI Projection Ole Miss by 48.4 points with a >99% probability to win game outright
No. 3 Texas A&M -7.5 at No. 19 Missouri
Saturday, 3:30 p.m., ABC
Records: Texas A&M 8-0, 2-0 vs. AP teams; Missouri 6-2, 0-2 vs. AP teams
Line Movement Alert: Opened Texas A&M -4.5, O/U 49.5
Money line: Off
Over/Under: 49.5 (O -105, U -115)
FPI Projection Texas A&M by 1.4 points with a 56% probability to win game outright
No. 6 Oregon -5.5 at Iowa
Saturday, 3:30 p.m.,
Records: Oregon 7-1, 1-1 vs. AP teams; Iowa 6-2, 0-2 vs. AP teams
Opening Line: Oregon -5.5, O/U 43.5
Money line: Off
Over/Under: 43.5 (O -105, U -115)
FPI Projection Oregon by 5.1 points with a 70% probability to win game outright
Syracuse at No. 18 Miami -28.5
Saturday, 3:30 p.m., ESPN
Records: Syracuse 3-6, 0-2 vs. AP teams; Miami 6-2, 3-0 vs. AP teams
Opening Line: Miami -27.5, O/U 46.5
Money line: Off
Over/Under: 46.5 (O -115, U -105)
FPI Projection Miami by 26.8 points with a 96% probability to win game outright
Auburn at No. 15 Vanderbilt -7.5
Saturday, 4 p.m., SEC Network
Records: Auburn 4-5, 0-4 vs. AP teams; Vanderbilt 7-2, 3-2 vs. AP teams
Opening Line: Vanderbilt -7.5, O/U 45.5
Money line: Off
Over/Under: 45.5 (O -115, U -105)
FPI Projection Vanderbilt by 5.7 points with a 71% probability to win game outright
No. 24 Washington -11.5 at Wisconsin
Saturday, 4:30 p.m.,
Records: Washington 6-2, 1-1 vs. AP teams; Wisconsin 2-6, 0-4 vs. AP teams
Opening Line: Washington -11.5, O/U 45.5
Money line: Off
Over/Under: 45.5 (O -110, U -110)
FPI Projection Washington by 6.2 points with a 73% probability to win game outright
Wake Forest at No. 12 Virginia -6.5
Saturday, 7 p.m., ESPN
Records: Wake Forest 5-3, 0-1 vs. AP teams; Virginia 8-1, 1-0 vs. AP teams
Opening Line: Virginia -6.5, O/U 49.5
Money line: Off
Over/Under: 48.5 (O EVEN, U -105)
FPI Projection Virginia by 8.6 points with a 78% probability to win game outright
California at No. 14 Louisville -20.5
Saturday, 7 p.m., ESPN2
Records: California 5-4, 0-1 vs. AP teams; Louisville 7-1, 1-1 vs. AP teams
Opening Line: Louisville -18.5, O/U 49.5
Money line: Off
Over/Under: 50.5 (O -115, U -105)
FPI Projection Louisville by 18.6 points with a 92% probability to win game outright
LSU at No. 4 Alabama -11.5
Saturday, 7:30 p.m., ABC
Records: LSU 5-3, 1-3 vs. AP teams; Alabama 7-1, 4-0 vs. AP teams
Opening Line: Alabama -10.5, O/U 50.5
Money line: Off
Over/Under: 50.5 (O -110, U -110)
FPI Projection Alabama by 9.9 points with a 81% probability to win game outright
Navy at No. 10 Notre Dame -25.5
Saturday, 7:30 p.m., NBC, Peacock
Records: Navy 7-1, 0-0 vs. AP teams; Notre Dame 6-2, 1-2 vs. AP teams
Opening Line: Notre Dame -24.5, O/U 55.5
Money line: Off
Over/Under: 56.5 (O -105, U -115)
FPI Projection Notre Dame by 27.2 points with a 97% probability to win game outright