Sunday's slate of Week 6 games wraps up with the Detroit Lions visiting the Kansas City Chiefs.
The NFC North-favorite Lions (+105) have won four straight since dropping their opener to the Green Bay Packers, while the Chiefs are coming off a loss to the Jacksonville Jaguars last Monday night.
Despite a 2-3 record, the Chiefs are 2.5-point favorites at home against the Lions in a game that has the highest total of the week (52.5).
Here are the odds and trends, plus picks, props and analysis from our experts to help you bet the game.
Note: Odds at time of publication. For the latest updates, visit ESPN BET. 
Jump to:
Game picks | Prop bets | Betting trends
Game bets
Total points UNDER 52.5 (-120)
Pamela Maldonado: Kansas City's defense leads the league in pressure rate, forcing opponents into shorter, inefficient possessions. That's where Detroit can get stuck -- moving the ball, but not finishing drives. Patrick Mahomes isn't running a track meet this year either; the Chiefs are more controlled, leaning on rhythm throws and long drives rather than downfield tosses. Detroit's ground game is explosive, but it's built on efficiency, not tempo. Kansas City's path to winning runs through its defense, discipline and limiting scores to field goals, not explosive plays. That script stays below 52.5.
Notable player props, bets
Jared Goff to go OVER 0.5 rushing yards (Even)
Liz Loza: This matchup is fraught with juicy storylines. Will the Lions' banged-up secondary wilt under the pressure of a Chiefs offense attempting to find a groove? Will the Chiefs' below-average run defense stop the Lions' talented smash-and-dash backfield? Flying under the radar, however, is Goff's potential to scramble against a Kansas City defense that has allowed the third-most rushing yards to opposing QBs. Goff has registered only nine rushing yards on the season, but the Chiefs have given up at least 15 rushing yards to QBs in every contest thus far in 2025. Goff figures to get loose at least once and clear a single rushing yard (a feat he has accomplished in two of five contests this season) on Sunday night.
Jahmyr Gibbs to go OVER 27.5 receiving yards (-120)
Matt Bowen: Gibbs has produced 30-plus receiving yards in three of five games played this season. Look for the Lions to get the ball out to Gibbs early on screen concepts, while he can be used as a matchup player versus linebackers when Goff sees pressure or man coverage.
Mike Clay, Daniel Dopp and Field Yates discuss why the receivers on the Titans and Chiefs have prime matchups in Week 6.
Jameson Williams to go OVER 45.5 receiving yards (-115)
Eric Moody: Williams is coming off a season-low nine receiving yards on just one target last week, but he averaged five targets per game over his previous four outings. Williams has cleared this line only once this season, but he surpassed it in 10 of 16 games last year. The Chiefs' secondary has allowed seven wide receivers to exceed 45.5 yards, several of whom were No. 2 receivers.
Amon-Ra St. Brown to record 70+ receiving yards, Anytime TD (+181)
Moody: St. Brown has recorded 70 or more receiving yards in each of his past four games, and he scored a touchdown in three of them (six TDs total). He has averaged 8.2 targets per game and should stay busy against the Chiefs in a game that has the highest point total of the week. With Goff under center, St. Brown has averaged 74.1 receiving yards and 0.5 touchdowns per game.
Betting trends
Courtesy of ESPN Research
The Lions have covered four straight games and are 16-4 ATS on the road since 2023.
Mahomes is 17-7-1 ATS when he is not at least a 3-point favorite (25-8-1 ATS including playoffs).
The Chiefs are 0-3 ATS against teams with winning records this season; the Lions are 3-0 against teams with losing records.