Ohio State, Oregon and Miami enter Week 6 as the top three teams in the AP Top 25. Ole Miss rises nine spots to fourth in the rankings after its win over LSU.
The No. 3 Hurricanes will take on ACC rival No. 18 Florida State on Saturday night in prime time on ABC. Florida State is looking to bounce back after its surprising loss to Virginia on Friday.
Also on ABC, No. 16 Vanderbilt will challenge the No. 10 Alabama, which rises back into the top 10 after knocking off Georgia in Athens. Last season, Vanderbilt shocked the Crimson Tide, pulling off a 40-35 upset of what was the No. 1 team in the nation. "College GameDay" will begin the day in Tuscaloosa on Saturday morning.
Oklahoma has reached the top five for the first time since joining the SEC, and Indiana has made the top 10 for the first time in consecutive seasons in program history, according to ESPN Research.
All times Eastern. For latest lines, go to ESPN BET
West Virginia at No. 23 BYU -18.5
Friday, 10:30 p.m., ESPN
Records: West Virginia 2-3, 0-0 vs. AP teams; BYU 4-0, 0-0 vs. AP teams
Opening line: BYU -20.5, O/U 49.5
Money line: Off
Over/under: 48.5 (O EVEN, U -120)
FPI projection: BYU by 23.5 points with a 95% probability to win outright
Kentucky at No. 12 Georgia -20.5
Saturday, noon, ABC
Records: Kentucky 2-2, 0-1 vs. AP teams; Georgia 3-1, 1-1 vs. AP teams
Opening line: Georgia -20.5, O/U 50.5
Money line: Off
Over/under: 48.5 (O -110, U -110)
FPI projection: Georgia by 16.9 points with a 90% probability to win outright
No. 14 Iowa State at Cincinnati -1.5
Saturday, Noon, ESPN2
Records: Iowa State 5-0, 1-0 vs. AP teams; Cincinnati 3-1, 0-0 vs. AP teams
Opening line: Cincinnati -1.5, O/U 51.5
Money line: Off
Over/under: 52.5 (O EVEN, U -120)
FPI projection: Iowa State by 0.3 points with a 51% probability to win outright
Wisconsin at No. 20 Michigan -16.5
Saturday, Noon, FOX
Records: Wisconsin 2-2, 0-1 vs. AP teams; Michigan 3-1, 0-1 vs. AP teams
Opening line: Michigan -16.5, O/U 41.5
Money line: Off
Over/under: 42.5 (O -115, U -105)
FPI projection: Michigan by 15.9 points with a 89% probability to win outright
No. 22 Illinois -9.5 at Purdue
Saturday, Noon, BTN
Records: Illinois 4-1, 1-1 vs. AP teams; Purdue 2-2, 0-1 vs. AP teams
Opening line: Illinois -7.5, O/U 54.5
Money line: Off
Over/under: 55.5 (O -110, U -110)
FPI projection: Illinois by 6.9 points with a 75% probability to win outright
No. 7 Penn State -24.5 at UCLA
Saturday, 3:30 p.m., CBS
Records: Penn State 3-1, 0-1 vs. AP teams; UCLA 0-4, 0-0 vs. AP teams
Opening line: Penn State -25.5, O/U 49.5
Money line: Off
Over/under: 50.5 (O -105, U -115)
FPI projection: Penn State by 20.3 points with a 93% probability to win outright
No. 9 Texas -6.5 at Florida
Saturday, 3:30 p.m., ESPN
Records: Texas 3-1, 0-1 vs. AP teams; Florida 1-3, 0-2 vs. AP teams
Opening line: Texas -7.5, O/U 43.5
Money line: Off
Over/under: 44.5 (O EVEN, U -120)
FPI projection: Texas by 7.7 points with a 77% probability to win outright
No. 16 Vanderbilt at No. 10 Alabama -9.5
Saturday, 3:30 p.m., ABC
Records: Vanderbilt 5-0, 1-0 vs. AP teams; Alabama 3-1, 1-0 vs. AP teams
Opening line: Alabama -11.5, O/U 56.5
Money line: Off
Over/under: 56.5 (O -105, U -115)
FPI projection: Alabama by 6.9 points with a 74% probability to win outright
Boise State at No. 21 Notre Dame -18.5
Saturday, 3:30 p.m., NBC, Peacock
Records: Boise State 3-1, 0-0 vs. AP teams; Notre Dame 2-2, 0-2 vs. AP teams
Opening line: Notre Dame -17.5, O/U 64.5
Money line: Off
Over/under: 64.5 (O -115, U -105)
FPI projection: Notre Dame by 18.9 points with a 92% probability to win outright
No. 24 Virginia at Louisville -6.5
Saturday, 3:30 p.m., ESPN2
Records: Virginia 4-1, 1-0 vs. AP teams; Louisville 4-0, 0-0 vs. AP teams
Opening line: Louisville -6.5, O/U 62.5
Money line: Off
Over/under: 62.5 (O -110, U -110)
FPI projection: Louisville by 1.5 points with a 56% probability to win outright
Kent State at No. 5 Oklahoma -45.5
Saturday, 4 p.m., SEC Network
Records: Kent State 1-3, 0-2 vs. AP teams; Oklahoma 4-0, 2-0 vs. AP teams
Opening line: Oklahoma -45.5, O/U 53.5
Money line: Off
Over/under: 53.5 (O -115, U -105)
FPI projection: Oklahoma by 46.2 points with a >99% probability to win outright
No. 11 Texas Tech -12.5 at Houston
Saturday, 7 p.m., ESPN
Records: Texas Tech 4-0, 1-0 vs. AP teams; Houston 4-0, 0-0 vs. AP teams
Opening line: Texas Tech -12.5, O/U 50.5
Money line: Off
Over/under: 50.5 (O -120, U EVEN)
FPI projection: Texas Tech by 6.9 points with a 75% probability to win outright
Minnesota at No. 1 Ohio State -23.5
Saturday, 7:30 p.m., NBC, Peacock
Records: Minnesota 3-1, 0-0 vs. AP teams; Ohio State 4-0, 1-0 vs. AP teams
Opening line: Ohio State -24.5, O/U 44.5
Money line: Off
Over/under: 44.5 (O -110, U -110)
FPI projection: Ohio State by 23.3 points with a 95% probability to win outright
No. 3 Miami -4.5 at No. 18 Florida State
Saturday, 7:30 p.m., ABC
Records: Miami 4-0, 2-0 vs. AP teams; Florida State 3-1, 1-0 vs. AP teams
Opening line: Miami -6.5, O/U 54.5
Money line: Off
Over/under: 54.5 (O -110, U -110)
FPI projection: Miami by 3.7 points with a 65% probability to win outright
Mississippi State at No. 6 Texas A&M -14.5
Saturday, 7:30 p.m., SEC Network
Records: Mississippi State 4-1, 1-1 vs. AP teams; Texas A&M 4-0, 1-0 vs. AP teams
Opening line: Texas A&M -13.5, O/U 58.5
Money line: Off
Over/under: 57.5 (O -115, U -105)
FPI projection: Texas A&M by 8.9 points with a 79% probability to win outright