Week 10 of the 2024 college football season features a marquee matchup between two ranked Big Ten rivals. No. 4 Ohio State travels to Happy Valley to face No. 3 Penn State. Penn State enters the rivalry game undefeated for the first time since 2017 as they look to end a seven-game losing streak to the Buckeyes.
Elsewhere in the country, Heisman favorite Dillon Gabriel and No. 1 Oregon visit Michigan at the Big House and No. 5 Miami, No. 21 Army, No. 11 Iowa State, No. 13 Indiana and No. 18 Pittsburgh look to stay undefeated in conference matchups Saturday.
The action all kicks off Friday night as Ashton Jeanty and No. 15 Boise State take on San Diego State.
Here are the odds and lines for games with Top 25 teams in Week 10.
All odds are accurate as of timestamp. For the latest odds go to ESPN BET.
San Diego State at No. 15 Boise State (-23.5)
Friday, 8 p.m. ET, FS1
Records: San Diego State 3-4; Boise State 6-1
Opening line: Boise State -24, O/U 57.5
Money line: San Diego State (+1300); Boise State (-4000)
Over/Under: 57.5 (O -105, U 115)
FPI Projection Boise State by 26.3 points, 95% probability to win
No. 4 Ohio State (-4) at No. 3 Penn State
Saturday, Noon ET, Fox
Records: Ohio State 6-1; Penn State 7-0
Opening line: Ohio State -4, O/U 47.5
Money line: Ohio State (-175); Penn State (+150)
Over/Under: 47.5 (O -105, U 115)
FPI Projection Ohio State by 4 points, 61% probability to win
Duke at No. 5 Miami (-20)
Saturday, Noon ET, ABC, ESPN+
Records: Duke 6-2; Miami 8-0
Opening line: Miami -21, O/U 55.5
Money line: Duke (+800); Miami (-1600)
Over/Under: 54.5 (O -115, U 105)
FPI Projection Miami by 20.4 points, 91% probability to win
No. 19 Ole Miss (-6.5) at Arkansas
Saturday, Noon ET, ESPN
Records: Ole Miss 6-2; Arkansas 5-3
Opening line: Ole Miss -6, O/U 55.5
Money line: Ole Miss (-240); Arkansas (+200)
Over/Under: 54.5 (O -115, U 105)
FPI Projection Ole Miss by 9.4 points, 74% probability to win
Air Force at No. 21 Army (-23.5)
Saturday, Noon ET, CBS, Paramount+
Records: Air Force 1-6; Army 7-0
Opening line: Army -23.5, O/U 40.5
Money line: Air Force (+1500); Army (-5000)
Over/Under: 40.5 (O -120, U EVEN)
FPI Projection Army by 25.8 points, 95% probability to win
Minnesota (-2) at No. 24 Illinois
Saturday, Noon ET, FS1
Records: Minnesota 5-3; Illinois 6-2
Opening line: Minnesota -1.5, O/U 46.5
Money line: Minnesota (-125); Illinois (+105)
Over/Under: 45.5 (O -105, U -115)
FPI Projection Minnesota by 1.6 points, 54% probability to win
No. 1 Oregon (-14.5) at Michigan
Saturday, 3:30 p.m. ET, CBS, Paramount+
Records: Oregon 8-0; Michigan 5-3
Opening line: Oregon -15.5, O/U 45.5
Money line: Oregon (-800); Michigan (+500)
Over/Under: 44.5 (O -120, U EVEN)
FPI Projection Oregon by 11.3 points, 78% probability to win
Florida vs. No. 2 Georgia (-16.5)
Saturday, 3:30 p.m. ET, ABC, ESPN+
Records: Florida 4-3; Georgia 6-1
Opening line: Georgia -17, O/U 52.5
Money line: Florida (+550); Georgia (-900)
Over/Under: 52.5 (O -105, U -115)
FPI Projection Georgia by 12.4 points, 80% probability to win
Texas Tech at No. 11 Iowa State (-14.5)
Saturday, 3:30 p.m. ET, ESPN
Records: Texas Tech 5-3; Iowa State 7-0
Opening line: Iowa State -15.5, O/U 57.5
Money line: Texas Tech (+450); Iowa State (-700)
Over/Under: 56.5 (O -110, U -110)
FPI Projection Iowa State by 13.3 points, 82% probability to win
No. 13 Indiana (-7) at Michigan State
Saturday, 3:30 p.m. ET, Peacock
Records: Indiana 8-0; Michigan State 4-4
Opening line: Indiana -7, O/U 50.5
Money line: Indiana (-250); Michigan State (+210)
Over/Under: 50.5 (O -115, U -105)
FPI Projection Indiana by 14.5 points, 83% probability to win
No. 17 Kansas State (-13.5) at Houston
Saturday, 3:30 p.m. ET, Fox
Records: Kansas State 7-1; Houston 3-5
Opening line: Kansas State -13, O/U 46.5
Money line: Kansas State (-650); Houston (+425)
Over/Under: 46.5 (O -110, U -110)
FPI Projection Kansas State by 15.1 points, 84% probability to win
No. 10 Texas A&M (-3.5) at South Carolina
Saturday, 7:30 p.m. ET, ABC, ESPN+
Records: Texas A&M 7-1; South Carolina 4-3
Opening line: Texas A&M -3.5, O/U 46.5
Money line: Texas A&M (-155); South Carolina (+135)
Over/Under: 45.5 (O -105, U -115)
FPI Projection Texas A&M by 1.5 points, 54% probability to win
Louisville at No. 11 Clemson (-11.5)
Saturday, 7:30 p.m. ET, ESPN
Records: Louisville 5-3; Clemson 6-1
Opening line: Clemson -11.5, O/U 61.5
Money line: Louisville (+340); Clemson (-450)
Over/Under: 61.5 (O -115, U -105)
FPI Projection Clemson by 6.4 points, 67% probability to win
Kentucky at No. 7 Tennessee (-16)
Saturday, 7:45 p.m. EET, SEC Network
Records: Kentucky 3-5; Tennessee 6-1
Opening line: Tennessee -15.5, O/U 45.5
Money line: Kentucky (+550); Tennessee (-900)
Over/Under: 45.5 (O -105, U -115)
FPI Projection Tennessee by 20.6 points, 91% probability to win
No. 18 Pittsburgh at No. 20 SMU (-7.5)
Saturday, 8 p.m. ET, ACC Network
Records: Pittsburgh 7-0; SMU 7-1
Opening line: SMU -7.5, O/U 60.5
Money line: Pittsburgh (+240); SMU (-290)
Over/Under: 59.5 (O -105, U -115)
FPI Projection SMU by 7.7 points, 70% probability to win