Wales' final chance to end their 16-game losing run will be in a home clash with England on Saturday, or they face waiting until July to break the unwanted streak.
Interim boss Matt Sherratt will need his side to rise to the occassion if they are to beat an in-form England side who are looking to end this Six Nations with four wins and maybe even the title.
A win for England would set up a grand finale for this year's tournament, as Scotland face leaders France on Saturday evening.
Can Steve Borthwick's team spoil the party in Paris?
Here is everything you need to know about Saturday's clash.
Key details:
When: Saturday, March 15 at 4.45 p.m. UK
Where: Principality Stadium, Cardiff
How to watch: You can wach live on the BBC (UK). You can also follow along with live updates on ESPN.
Officials: Referee: Nic Berry (Aus)
Assistant Referees: Nika Amashukeli (Geo) & Hollie Davidson (Sco)
Television Match Official: Mike Adamson (Sco)
Lineups:
Wales: Nicky Smith, Elliot Dee, WillGriff John, Will Rowlands, Dafydd Jenkins, Aaron Wainwright, Jac Morgan (captain), Taulupe Faletau, Tomos Williams, Gareth Anscombe, Joe Roberts, Ben Thomas, Max Llewellyn, Ellis Mee, Blair Murray.
Replacements: Dewi Lake, Gareth Thomas, Keiron Assiratti, Teddy Williams, Tommy Reffell, Rhodri Williams, Jarrod Evans, Nick Tompkins.
England: Ellis Genge, Luke Cowan-Dickie, Will Stuart, Maro Itoje, Ollie Chessum, Tom Curry, Ben Curry, Ben Earl, Alex Mitchell, Fin Smith, Elliot Daly, Fraser Dingwall, Tommy Freeman, Tom Roebuck, Marcus Smith.
Replacements: Jamie George, Fin Baxter, Joe Heyes, Chandler Cunningham-South, Henry Pollock, Tom Willis, Jack van Poortvliet, George Ford.
Team news:
Wales: Aaron Wainwright has been recalled to the starting side for Wales' clash against England in Cardiff on Saturday.
After starting on the bench against Scotland last week, Wainwright comes into the starting XV at flanker while Tommy Reffell moves to the replacements.
The rest of the Welsh pack is unchanged for the visit of England, who need a bonus point victory at the Principality Stadium to keep their slim Six Nations title hopes alive.
Interim coach Matt Sherratt has made one change to the backline with Joe Roberts starting on the wing in place of Tom Rogers, who has fractured his thumb.
England: England have made four changes for their final Six Nations match against Wales with Marcus Smith recalled, and starts for Luke Cowan-Dickie, Tom Roebuck and Ben Curry.
Elsewhere, Tommy Freeman moves to outside centre in place of the injured Ollie Lawrence while Henry Pollock is in line to make his debut from the bench.
Steve Borthwick has opted to reshuffle the team for Saturday's match with four changes and three positional shifts.
Lawrence misses out with an Achilles injury and his absence sees Borthwick move the backs around. Marcus Smith is recalled at fullback after starting on the bench for their win over Italy, while Roebuck and Elliot Daly start on the wings.
Daly was at No.15 for Italy, but moved into the centres when Lawrence was injured, and he's now on the left wing for Wales. Roebuck will win his fourth cap on the right wing.
Their inclusion means Borthwick has shifted Freeman to No.13 as Lawrence's replacement. He lines up with Fraser Dingwall in the centres but that means Ollie Sleightholme -- who scored twice against Italy -- drops out of the matchday squad.
In the pack, Cowan-Dickie replaces Jamie George at hooker and Ben Curry comes in for Tom Willis in the back-row.
Information from Reuters contributed to the team news of this report.
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