Big wins over France and Scotland have put England in a strong position heading into the final two weeks of the tournament.
Meanwhile, Italy are coming off a heavy defeat to France in Round 3 and will hope for much better showing at Twickenham.
Here is everything you need to know about Sunday's clash.
Key details:
When: Sunday, March 9 at 3 p.m. UK
Where: Allianz Stadium, Twickenham
How to watch: You can wach live on the ITV (UK). You can also follow along with live updates on ESPN.
Officials: Referee: Andrew Brace (Ire)
Assistant Referees: Craig Evans (Wal) & Luc Ramos (Fra)
Television Match Official: Marius Jonker (SA)
Lineups:
England: Elliot Daly, Tommy Freeman, Ollie Lawrence, Fraser Dingwall, Ollie Sleightholme, Fin Smith, Alex Mitchell; Ellis Genge, Jamie George, Will Stuart, Maro Itoje, Ollie Chessum, Tom Curry, Ben Earl, Tom Willis
Replacements: Luke Cowan-Dickie, Fin Baxter, Joe Heyes, Ted Hill, Chandler Cunningham-South, Ben Curry, Jack van Poortvliet, Marcus Smith
Italy: Danilo Fischetti, Giacomo Nicotera, Marco Riccioni, Niccolo Cannone, Federico Ruzza, Sebastian Negri, Michele Lamaro (captain), Ross Vintcent, Stephen Varney, Paolo Garbisi, Matt Gallagher, Tommaso Menoncello, Juan Ignacio Brex, Monty Ioane, Ange Capuozzo.
Replacements: Gianmarco Lucchesi, Mirco Spagnolo, Simone Ferrari, Riccardo Favretto, Manuel Zuliani, Lorenzo Cannone, Martin Page-Relo, Tommaso Allan.
Team news:
England:
Marcus Smith and Henry Slade have been dropped for England's Six Nations clash with Italy, while Jamie George is in line to win his 100th cap having been named in the starting line-up for Sunday's match.
Steve Borthwick has made three changes for Sunday's Test at Twickenham with Elliot Daly replacing Marcus Smith at fullback, and Fraser Dingwall starting in the centres in place of Slade.
Elsewhere, George replaces Luke Cowan-Dickie at hooker. The other switch comes on the bench as Jack van Poortvliet comes in for Harry Randall as replacement scrum-half.
England head into the clash with Italy with two wins from three. They opened their campaign with defeat to Ireland but followed that up with a 26-25 victory over France, and a 16-15 triumph over Scotland.
And as they prepare to face Italy, Borthwick has shifted things up in the backline. Daly makes his first start for England since the Six Nations last year, and comes into the side at fullback.
Marcus Smith started the tournament at fly-half, then shifted to fullback for their previous two Tests but he's named among the replacements, with Daly preferred.
Northampton Saints' centre Dingwall will earn his third cap for England on Sunday, having featured twice in last year's championship. He gets the nod at inside centre where he will partner Ollie Lawrence.
Italy: Italy have made six changes to the side that were dismantled by France in Rome. Crucially, Ange Capuozzo shifts to fullback as Monty Ioane comes back into the side on the right wing after he missed the France clash through injury.
On the left wing, Matt Gallagher is set to play his first Six Nations Test. Stephen Varney has been called in to make his first appearance of the tournament at scrum-half.
Information from Reuters contributed to the team news of this report.
