San Francisco49ers
- 6-8
- 4th in NFC West
San Francisco 49ers Schedule 2021
| Postseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| WC | Sun, Jan 16 | W23-17 | 10-7 | Garoppolo 172 | Mitchell 96 | Aiyuk 66 | |||
| DIV | Sat, Jan 22 | W13-10 | 10-7 | Garoppolo 131 | Mitchell 53 | Kittle 63 | |||
| CONF | Sun, Jan 30 | L20-17 | 10-7 | Garoppolo 232 | Samuel Sr. 26 | Samuel Sr. 72 | |||
| Regular Season | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sun, Sep 12 | W41-33 | 1-0 | Garoppolo 314 | Mitchell 104 | Samuel Sr. 189 | |||
| 2 | Sun, Sep 19 | W17-11 | 2-0 | Garoppolo 189 | Mitchell 42 | Samuel Sr. 93 | |||
| 3 | Sun, Sep 26 | L30-28 | 2-1 | Garoppolo 257 | Sermon 31 | Kittle 92 | |||
| 4 | Sun, Oct 3 | L28-21 | 2-2 | Garoppolo 165 | Sermon 89 | Samuel Sr. 156 | |||
| 5 | Sun, Oct 10 | L17-10 | 2-3 | Lance 192 | Lance 89 | Samuel Sr. 58 | |||
| 6 | BYE WEEK | ||||||||
| 7 | Sun, Oct 24 | L30-18 | 2-4 | Garoppolo 181 | Mitchell 107 | Samuel Sr. 100 | |||
| 8 | Sun, Oct 31 | W33-22 | 3-4 | Garoppolo 322 | Mitchell 137 | Samuel Sr. 171 | |||
| 9 | Sun, Nov 7 | L31-17 | 3-5 | Garoppolo 326 | Mitchell 36 | Kittle 101 | |||
| 10 | Mon, Nov 15 | W31-10 | 4-5 | Garoppolo 182 | Mitchell 91 | Samuel Sr. 97 | |||
| 11 | Sun, Nov 21 | W30-10 | 5-5 | Garoppolo 176 | Samuel Sr. 79 | Aiyuk 85 | |||
| 12 | Sun, Nov 28 | W34-26 | 6-5 | Garoppolo 230 | Mitchell 133 | Aiyuk 91 | |||
| 13 | Sun, Dec 5 | L30-23 | 6-6 | Garoppolo 299 | Mitchell 66 | Kittle 181 | |||
| 14 | Sun, Dec 12 | W26-23 OT | 7-6 | Garoppolo 296 | Wilson Jr. 56 | Kittle 151 | |||
| 15 | Sun, Dec 19 | W31-13 | 8-6 | Garoppolo 235 | Wilson Jr. 110 | Kittle 93 | |||
| 16 | Thu, Dec 23 | L20-17 | 8-7 | Garoppolo 322 | Wilson Jr. 45 | Samuel Sr. 159 | |||
| 17 | Sun, Jan 2 | W23-7 | 9-7 | Lance 249 | Mitchell 119 | Aiyuk 94 | |||
| 18 | Sun, Jan 9 | W27-24 OT | 10-7 | Garoppolo 316 | Mitchell 85 | Aiyuk 107 | |||
| Preseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sat, Aug 14 | L19-16 | 0-1 | Lance 128 | Hasty 63 | Sherfield Sr. 80 | |||
| 2 | Sun, Aug 22 | W15-10 | 1-1 | Lance 102 | Gallman 72 | Sherfield Sr. 50 | |||
| 3 | Sun, Aug 29 | W34-10 | 2-1 | Garoppolo 64 | Gallman 60 | Sherfield Sr. 26 | |||