New-look Patriots under coach Mike Vrabel face big test in preparing to play AFC East-leading Bills

— Mike Vrabel is well aware of how the tables have turned in the AFC East rivalry between New England and Buffalo since his eight seasons as a Patriots linebacker in the 2000s.
Oct 2, 2025, 05:25 pm - AP
Game Odds
2025-10-06T00:20ZOpenSpreadTotalML
New England PatriotsPatriotsNE
(2-2)
(2-2, 1-0 Away)
o49.5
-110
+8.5
-110
o48.5
-115
+340
Buffalo BillsBillsBUF
(4-0)
(4-0, 3-0 Home)
-8.5
-105
-8.5
-110
u48.5
-105
-450

Season Leaders

PatriotsBills
Drake Maye
988
D. MayeQB
91/123, 7 TD, 2 INT
988
Passing Yards
Josh Allen
964
J. AllenQB
85/121, 7 TD, 1 INT
964
Rhamondre Stevenson
125
R. StevensonRB
31 CAR
125
Rushing Yards
James Cook
401
J. CookRB
75 CAR, 5 TD
401
Stefon Diggs
213
S. DiggsWR
19 REC
213
Receiving Yards
Keon Coleman
203
K. ColemanWR
17 REC, 1 TD
203
Harold Landry III
3.5
H. Landry IIILB
3.5
Sacks
DaQuan Jones
2
D. JonesDT
2
Robert Spillane
31
R. SpillaneLB
31
Tackles
Terrel Bernard
20
T. BernardLB
20

Injury Report

New England Patriots
NameStatusEst. Return
K'Lavon ChaissonK. ChaissonLB
QuestionableKnee
Oct 5
Milton WilliamsM. WilliamsDE
QuestionableAnkle
Oct 5
Marte MapuM. MapuLB
QuestionableNeck
Oct 5
Carlton Davis IIIC. Davis IIICB
QuestionableIllness
Oct 5
Jaylinn HawkinsJ. HawkinsS
QuestionableHamstring
Oct 5
Buffalo Bills
NameStatusEst. Return
Dorian StrongD. StrongCB
QuestionableNeck
Oct 5
T.J. SandersT.J. SandersDT
QuestionableKnee
Oct 5
Matt MilanoM. MilanoLB
QuestionablePectoral
Oct 5
Ed OliverE. OliverDT
QuestionableAnkle
Oct 5
Dorian WilliamsD. WilliamsLB
QuestionableKnee
Oct 5

LAST FIVE GAMES

Patriots
DATEOPPRESULT
9/28/25vsCARW42-13
9/21/25vsPITL21-14
9/14/25@MIAW33-27
9/7/25vsLVL20-13
8/21/25@NYGL42-10
Bills
DATEOPPRESULT
9/28/25vsNOW31-19
9/18/25vsMIAW31-21
9/14/25@NYJW30-10
9/7/25vsBALW41-40
8/23/25@TBW23-19
Data is currently unavailable.