QB Brock Purdy expected to return from his toe injury when 49ers travel to face Cardinals

San Francisco (6-4) at Arizona (3-6)
Nov 13, 2025, 03:33 pm - AP
Game Odds
2025-11-16T21:05ZOpenSpreadTotalML
San Francisco 49ers49ersSF
(6-4)
(6-4, 4-2 Away)
-2.5
-120
-2.5
-125
o48.5
-105
-165
Arizona CardinalsCardinalsARI
(3-6)
(3-6, 1-3 Home)
u47.5
EVEN
+2.5
+105
u48.5
-115
+140

Season Leaders

49ersCardinals
Mac Jones
2,151
M. JonesQB
201/289, 13 TD, 6 INT
2,151
Passing Yards
Jacoby Brissett
1,118
J. BrissettQB
95/156, 8 TD, 1 INT
1,118
Christian McCaffrey
626
C. McCaffreyRB
180 CAR, 4 TD
626
Rushing Yards
Emari Demercado
233
E. DemercadoRB
26 CAR
233
Christian McCaffrey
692
C. McCaffreyRB
69 REC, 4 TD
692
Receiving Yards
Trey McBride
603
T. McBrideTE
61 REC, 6 TD
603
Bryce Huff
4
B. HuffDE
4
Sacks
Josh Sweat
8
J. SweatLB
8
Dee Winters
67
D. WintersLBQ
67
Tackles
Akeem Davis-Gaither
64
A. Davis-GaitherLB
64

Injury Report

San Francisco 49ers
NameStatusEst. Return
Deommodore LenoirD. LenoirCB
QuestionableCalf
Nov 16
Ricky PearsallR. PearsallWR
QuestionableKnee - PCL
Nov 16
Alfred CollinsA. CollinsDT
QuestionableHip
Nov 16
Dee WintersD. WintersLB
QuestionableKnee
Nov 16
Brandon AiyukB. AiyukWR
PUP-RKnee - ACL + MCL
Nov 24
Arizona Cardinals
NameStatusEst. Return
Evan BrownE. BrownC
QuestionableFoot
Nov 16
Will HernandezW. HernandezG
QuestionableKnee
Nov 16
BJ OjulariB. OjulariLB
PUP-RKnee - ACL
Nov 16
Baron BrowningB. BrowningLB
QuestionableConcussion
Nov 16
Walter Nolen IIIW. Nolen IIIDT
QuestionableKnee
Nov 16

LAST FIVE GAMES

49ers
DATEOPPRESULT
11/9/25vsLARL42-26
11/2/25@NYGW34-24
10/26/25@HOUL26-15
10/19/25vsATLW20-10
10/12/25@TBL30-19
Cardinals
DATEOPPRESULT
11/9/25@SEAL44-22
11/3/25@DALW27-17
10/19/25vsGBL27-23
10/12/25@INDL31-27
10/5/25vsTENL22-21
Data is currently unavailable.