Houston's Ryans faces former boss San Francisco's Shanahan for 1st time when Texans host Niners

San Francisco (5-2) at Houston (2-4)
Oct 24, 2025, 06:30 pm - AP
Game Odds
2025-10-26T17:00ZOpenSpreadTotalML
San Francisco 49ers49ersSF
(5-2)
(5-2, 3-1 Away)
o43.5
-110
+1.5
-110
o42.5
-110
+105
Houston TexansTexansHOU
(2-4)
(2-4, 1-1 Home)
-1.5
-105
-1.5
-110
u42.5
-110
-125

Season Leaders

49ersTexans
Mac Jones
1,404
M. JonesQB
130/194, 6 TD, 4 INT
1,404
Passing Yards
C.J. Stroud
1,305
C.J. StroudQB
125/193, 9 TD, 4 INT
1,305
Christian McCaffrey
465
C. McCaffreyRB
132 CAR, 3 TD
465
Rushing Yards
Nick Chubb
265
N. ChubbRB
63 CAR, 2 TD
265
Christian McCaffrey
516
C. McCaffreyRB
53 REC, 3 TD
516
Receiving Yards
Nico Collins
339
N. CollinsWRO
26 REC, 3 TD
339
Bryce Huff
4
B. HuffDEO
4
Sacks
Danielle Hunter
4
D. HunterDE
4
Fred Warner
51
F. WarnerLBIR
51
Tackles
Azeez Al-Shaair
38
A. Al-ShaairLB
38

Injury Report

San Francisco 49ers
NameStatusEst. Return
Jake BrendelJ. BrendelC
OutHamstring
Nov 2
Luke GiffordL. GiffordLB
QuestionableHamstring
Oct 26
Deommodore LenoirD. LenoirCB
QuestionableQuadriceps
Oct 26
Bryce HuffB. HuffDE
OutHamstring
Nov 2
Yetur Gross-MatosY. Gross-MatosDE
OutKnee
Nov 2
Houston Texans
NameStatusEst. Return
Alijah HuzzieA. HuzzieCB
NFI-RKnee
Nov 2
Denico AutryD. AutryDE
QuestionableKnee
Oct 26
Christian KirkC. KirkWR
OutHamstring
Dec 7
Nico CollinsN. CollinsWR
OutConcussion
Nov 2
Cade StoverC. StoverTE
IRFoot
Oct 26

LAST FIVE GAMES

49ers
DATEOPPRESULT
10/19/25vsATLW20-10
10/12/25@TBL30-19
10/2/25@LARW26-23 OT
9/28/25vsJAXL26-21
9/21/25vsARIW16-15
Texans
DATEOPPRESULT
10/20/25@SEAL27-19
10/5/25@BALW44-10
9/28/25vsTENW26-0
9/21/25@JAXL17-10
9/15/25vsTBL20-19
Data is currently unavailable.