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For those rooting for chaos in March Madness, picking upsets in the opening round can be an enticing proposition. But which double-digit seeds actually have a chance to pull it off? In 12 of the past 13 NCAA tournaments, a First Four team has advanced to the second round. And 11 seeds are catching up with 12 seeds in their historical upset rates. To find this year's potential candidates, we consulted ESPN's BPI projections to identify the 10 matchups with the highest probabilities of an upset -- just keep in mind that probability does not mean predictability when filling out your brackets. Note: Because two No. 6 vs. No. 11 games are still to be determined by the outcomes of First Four games on Tuesday and Wednesday, the Giant Killers model takes all possible matchups into consideration.   
(11) North Carolina vs. (6) Ole MissUpset chance: 55%
Potential matchup: 4:05 p.m. ET on Friday The percentage might come as a surprise, but as we mentioned earlier, a First Four team has gone on to win a first-round game in 12 of 13 tournaments. So why not the controversial "last team in" Carolina?
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