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Giant Killers: Complete upset picks for every region in the March Madness bracket 2021

NCAA Men's Basketball, Morehead State Eagles, UC Santa Barbara Gauchos, Eastern Washington Eagles, Texas Southern Tigers, Wichita State Shockers, North Texas Mean Green, West Virginia Mountaineers, Oregon State Beavers, UCLA Bruins, Arkansas Razorbacks, Hartford Hawks, Virginia Cavaliers, Tennessee Volunteers, Michigan State Spartans, Colgate Raiders, UNC Greensboro Spartans, Florida State Seminoles, Villanova Wildcats, Alabama Crimson Tide, Iowa Hawkeyes, Abilene Christian Wildcats, Drexel Dragons, Oral Roberts Golden Eagles, Purdue Boilermakers, Colorado Buffaloes, Creighton Bluejays, Baylor Bears, Michigan Wolverines, Syracuse Orange, Cleveland State Vikings, Iona Gaels, Drake Bulldogs, Houston Cougars, Texas Tech Red Raiders, BYU Cougars, Ohio State Buckeyes, Ohio Bobcats, Texas Longhorns, App State Mountaineers, Norfolk State Spartans, Gonzaga Bulldogs, Georgetown Hoyas, Utah State Aggies, USC Trojans, San Diego State Aztecs, Oklahoma State Cowboys, Grand Canyon Lopes, Mount St. Mary's Mountaineers, Winthrop Eagles, Illinois Fighting Illini, Liberty Flames, Kansas Jayhawks

Giant Killers is back for our 15th annual metrics-based forecast of big upsets in the NCAA tournament. As usual, we're analyzing each Giant vs. Killer game in the first round. (Quick reminder: A Giant Killer is any team that defeats an opponent seeded at least five lines higher in any round.)

Our statistical model yields an upset probability for each game based on both the BPI of each team and on the stylistic factors that have most often led to tournament upsets in the past.

As always, we've sorted our picks into four categories based on the likelihood of an upset: best bets, worth a long look, not completely ridiculous and, last and very likely least, stay away. Hopefully the titles are self-explanatory.

Got that? Now, let's get to the good stuff. Here are the upsets in the making:

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