Seth WalderJohn Gasaway 4y

Giant Killers: Complete upset picks for every region in the March Madness bracket 2021

Men's College Basketball, UCLA Bruins, BYU Cougars, Georgetown Hoyas, Colorado Buffaloes, Michigan State Spartans, Abilene Christian Wildcats, Texas Longhorns, UNC Greensboro Spartans, Florida State Seminoles, Iona Gaels, Alabama Crimson Tide, Mount St. Mary's Mountaineers, Texas Southern Tigers, Michigan Wolverines, Colgate Raiders, Arkansas Razorbacks, North Texas Mean Green, Purdue Boilermakers, Utah State Aggies, Texas Tech Red Raiders, Winthrop Eagles, Villanova Wildcats, Oral Roberts Golden Eagles, Ohio State Buckeyes, Hartford Hawks, Baylor Bears, UC Santa Barbara Gauchos, Creighton Bluejays, Wichita State Shockers, USC Trojans, Drake Bulldogs, Ohio Bobcats, Virginia Cavaliers, Eastern Washington Eagles, Kansas Jayhawks, Grand Canyon Antelopes, Iowa Hawkeyes, Norfolk St Spartans, Appalachian State Mountaineers, Gonzaga Bulldogs, Syracuse Orange, San Diego State Aztecs, Liberty Flames, Oklahoma State Cowboys, Morehead State Eagles, West Virginia Mountaineers, Oregon State Beavers, Tennessee Volunteers, Drexel Dragons, Illinois Fighting Illini, Houston Cougars, Cleveland State Vikings

Giant Killers is back for our 15th annual metrics-based forecast of big upsets in the NCAA tournament. As usual, we're analyzing each Giant vs. Killer game in the first round. (Quick reminder: A Giant Killer is any team that defeats an opponent seeded at least five lines higher in any round.)

Our statistical model yields an upset probability for each game based on both the BPI of each team and on the stylistic factors that have most often led to tournament upsets in the past.

As always, we've sorted our picks into four categories based on the likelihood of an upset: best bets, worth a long look, not completely ridiculous and, last and very likely least, stay away. Hopefully the titles are self-explanatory.

Got that? Now, let's get to the good stuff. Here are the upsets in the making:

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