There are three ranked matchups this weekend, starting with No. 1 Ohio State on the road against No. 17 Illinois and No. 8 Alabama also on the road against No. 14 Missouri, both at noon ET.
At 3:30 p.m. ET, No. 7 Indiana and No. 3 Oregon clash in their first head-to-head matchup as Big Ten rivals. Both teams have at least a 60% chance to reach the College Football Playoff, even with a loss, according to ESPN Analytics.
Texas Tech entered the top 10 for the first time since 2013, and No. 9 is their highest ranking since 2008, when they rose as high as No. 2. No. 16 Notre Dame and No. 25 Florida State are the only two-loss teams ranked this week.
Elsewhere, Florida is playing an AP top-10 opponent (No. 5 Texas A&M) for a fourth straight game, making them the first team to do so in the same regular season since 1968, according to ESPN Research.
All times Eastern. For latest lines, go to ESPN BETÂ 
No. 24 South Florida at North Texas -1.5
Friday, 7:30 p.m., ESPN2
Records: South Florida 4-1, 2-1 vs. AP teams; North Texas 5-0, 0-0 vs. AP teams
Opening Line: North Texas -1.5, O/U 66.5
Money line: South Florida (+105); North Texas (-125)
Over/Under: 66.5 (O -110, U -110)
FPI Projection North Texas by 0.8 points with a 53% probability to win game outright
No. 1 Ohio State -14.5 at No. 17 Illinois
Saturday, Noon, FOX
Records: Ohio State 5-0, 1-0 vs. AP teams; Illinois 5-1, 1-1 vs. AP teams
Opening Line: Ohio State -16.5, O/U 48.5
Money line: Ohio State (-750); Illinois (+475)
Over/Under: 50.5 (O -110, U -110)
FPI Projection Ohio State by 10.6 points with a 82% probability to win game outright
No. 8 Alabama -2.5 at No. 14 Missouri
Saturday, Noon, ABC
Records: Alabama 4-1, 2-0 vs. AP teams; Missouri 5-0, 0-0 vs. AP teams
Line Movement Alert: Opened Alabama -5.5, O/U 54.5
Money line: Alabama (-150); Missouri (+130)
Over/Under: 51.5 (O -110, U -110)
FPI Projection Alabama by 3.4 points with a 63% probability to win game outright
Pittsburgh at No. 25 Florida State -10.5
Saturday, Noon, ESPN
Records: Pittsburgh 3-2, 0-0 vs. AP teams; Florida State 3-2, 1-1 vs. AP teams
Opening Line: Florida State -9.5, O/U 58.5
Money line: Pittsburgh (+290); Florida State (-380)
Over/Under: 56.5 (O EVEN, U -120)
FPI Projection Florida State by 7.9 points with a 77% probability to win game outright
Washington State at No. 4 Ole Miss -31.5
Saturday, 12:45 p.m., SEC Network
Records: Washington State 3-2, 0-0 vs. AP teams; Ole Miss 5-0, 1-0 vs. AP teams
Opening Line: Ole Miss -32.5, O/U 59.5
Money line: Off
Over/Under: 58.5 (O -110, U -110)
FPI Projection Ole Miss by 34.7 points with a 98% probability to win game outright
No. 7 Indiana at No. 3 Oregon -7.5
Saturday, 3:30 p.m., CBS
Records: Indiana 5-0, 1-0 vs. AP teams; Oregon 5-0, 1-0 vs. AP teams
Opening Line: Oregon -7.5, O/U 54.5
Money line: Indiana (+225); Oregon (-275)
Over/Under: 53.5 (O EVEN, U -120)
FPI Projection Oregon by 4.8 points with a 68% probability to win game outright
No. 6 Oklahoma at Texas -1.5
Saturday, 3:30 p.m., ABC
Records: Oklahoma 5-0, 2-0 vs. AP teams; Texas 3-2, 0-1 vs. AP teams
Opening Line: Texas -2.5, O/U 42.5
Money line: Oklahoma (-115); Texas (-105)
Over/Under: 45.5 (O -105, U -115)
FPI Projection Texas by 2.5 points with a 61% probability to win game outright
Virginia Tech at No. 13 Georgia Tech -14.5
Saturday, 3:30 p.m., ACC Network
Records: Virginia Tech 2-4, 0-1 vs. AP teams; Georgia Tech 5-0, 1-0 vs. AP teams
Opening Line: Georgia Tech -14.5, O/U 55.5
Money line: Virginia Tech (+425); Georgia Tech (-650)
Over/Under: 54.5 (O -105, U -115)
FPI Projection Georgia Tech by 9.3 points with a 80% probability to win game outright
NC State at No. 16 Notre Dame -22.5
Saturday, 3:30 p.m., Peacock
Records: NC State 4-2, 0-0 vs. AP teams; Notre Dame 3-2, 0-2 vs. AP teams
Opening Line: Notre Dame -22.5, O/U 62.5
Money line: NC State (+1000); Notre Dame (-2000)
Over/Under: 58.5 (O -105, U -115)
FPI Projection Notre Dame by 19.4 points with a 92% probability to win game outright
No. 22 Iowa State -2.5 at Colorado
Saturday, 3:30 p.m., ESPN
Records: Iowa State 5-1, 1-0 vs. AP teams; Colorado 2-4, 0-1 vs. AP teams
Opening Line: Iowa State -4.5, O/U 53.5
Money line: Iowa State (-140); Colorado (+120)
Over/Under: 52.5 (O EVEN, U -120)
FPI Projection Iowa State by 3.3 points with a 63% probability to win game outright
Arkansas at No. 12 Tennessee -11.5
Saturday, 4:15 p.m., SEC Network
Records: Arkansas 2-3, 0-2 vs. AP teams; Tennessee 4-1, 0-1 vs. AP teams
Opening Line: Tennessee -12.5, O/U 69.5
Money line: Arkansas (+340); Tennessee (-450)
Over/Under: 67.5 (O -120, U EVEN)
FPI Projection Tennessee by 10.9 points with a 82% probability to win game outright
Florida at No. 5 Texas A&M -7.5
Saturday, 7 p.m., ESPN
Records: Florida 2-3, 1-2 vs. AP teams; Texas A&M 5-0, 1-0 vs. AP teams
Opening Line: Texas A&M -8.5, O/U 47.5
Money line: Florida (+240); Texas A&M (-290)
Over/Under: 47.5 (O -115, U -115)
FPI Projection Texas A&M by 6.8 points with a 74% probability to win game outright
Kansas at No. 9 Texas Tech -14.5
Saturday, 7:30 p.m., FOX
Records: Kansas 4-2, 0-0 vs. AP teams; Texas Tech 5-0, 1-0 vs. AP teams
Opening Line: Texas Tech -14.5, O/U 60.5
Money line: Kansas (+450); Texas Tech (-700)
Over/Under: 59.5 (O -105, U -115)
FPI Projection Texas Tech by 6.8 points with a 74% probability to win game outright
No. 10 Georgia -3.5 at Auburn
Saturday, 7:30 p.m., ABC
Records: Georgia 4-1, 1-1 vs. AP teams; Auburn 3-2, 0-2 vs. AP teams
Opening Line: Georgia -3.5, O/U 46.5
Money line: Georgia (-175); Auburn (+150)
Over/Under: 46.5 (O -105, U -115)
FPI Projection Georgia by 3.7 points with a 65% probability to win game outright
No. 15 Michigan at USC -2.5
Saturday, 7:30 p.m., NBC
Records: Michigan 4-1, 0-1 vs. AP teams; USC 4-1, 0-1 vs. AP teams
Opening Line: USC -1.5, O/U 57.5
Money line: Michigan (+110); USC (-130)
Over/Under: 56.5 (O -105, U -115)
FPI Projection USC by 5 points with a 68% probability to win game outright
South Carolina at No. 11 LSU -9.5
Saturday, 7:45 p.m., SEC Network
Records: South Carolina 3-2, 0-1 vs. AP teams; LSU 4-1, 1-1 vs. AP teams
Opening Line: LSU -9.5, O/U 44.5
Money line: South Carolina (+280); LSU (-360)
Over/Under: 44.5 (O EVEN, U -120)
FPI Projection LSU by 6 points with a 72% probability to win game outright
No. 18 BYU -2.5 at Arizona
Saturday, 8 p.m., ESPN2
Records: BYU 5-0, 0-0 vs. AP teams; Arizona 4-1, 0-1 vs. AP teams
Opening Line: BYU -2.5, O/U 47.5
Money line: BYU (-130); Arizona (+110)
Over/Under: 46.5 (O -120, U EVEN)
FPI Projection BYU by 5.2 points with a 69% probability to win game outright
No. 21 Arizona State at Utah -8.5
Saturday, 10:15 p.m., ESPN
Records: Arizona State 4-1, 1-0 vs. AP teams; Utah 4-1, 0-1 vs. AP teams
Line Movement Alert: Opened Utah -4.5, O/U 48.5
Money line: Arizona State (+250); Utah (-300)
Over/Under: 45.5 (O -105, U -115)
FPI Projection Utah by 5.2 points with a 70% probability to win game outright
