Greg Peterson 10d

Men's March Madness 2025: Best bets for the Sweet 16

Betting, Men's College Basketball, Arkansas Razorbacks, Texas Tech Red Raiders, Houston Cougars, Tennessee Volunteers, Alabama Crimson Tide, Florida Gators, Maryland Terrapins, BYU Cougars, Arizona Wildcats, Duke Blue Devils, Kentucky Wildcats, Auburn Tigers, Michigan Wolverines, Purdue Boilermakers

The 2025 men's NCAA tournament continues Thursday and Friday with the Sweet 16, and all four No. 1 seeds remain.

So what can we expect in the Sweet 16, and which point spreads and over/unders are worth betting on? 

Let's factor in team trends, injuries, momentum and more to identify the smartest wagers to make over the weekend.

Odds are accurate as of publication time. For the latest odds, go to ESPN BET. 

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